Evidence map›Paper›PMID 37587480›Full record

ArticleParasites & vectors2023

Honokiol induces apoptosis-like death in Cryptocaryon irritans Tomont.

Zi-Chen Zhao, Man-Yi Jiang, Ji-Hui Huang, Chuan Lin, Wei-Liang Guo, Zhi-Hong Zhong, Qing-Qin Huang, Shao-Long Liu, Heng-Wei Deng, Yong-Can Zhou

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parasites & vectors, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Baohuoside I CombatedAntioxidants (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Zi-Chen ZhaoHainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, Haikou, 570228, People's Republic of China.
Man-Yi JiangHainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, Haikou, 570228, People's Republic of China.
Ji-Hui HuangHainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, Haikou, 570228, People's Republic of China.
Chuan LinAquaculture Department, Hainan Agriculture School, Haikou, 571101, People's Republic of China.
Wei-Liang GuoHainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, Haikou, 570228, People's Republic of China. guowl07@hainanu.edu.cn.
Zhi-Hong ZhongHainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, Haikou, 570228, People's Republic of China.
Qing-Qin HuangHainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, Haikou, 570228, People's Republic of China.
Shao-Long LiuHainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, Haikou, 570228, People's Republic of China.
Heng-Wei DengHainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, Haikou, 570228, People's Republic of China.
Yong-Can ZhouHainan Provincial Key Laboratory for Tropical Hydrobiology and Biotechnology, College of Marine Science, Hainan University, Haikou, 570228, People's Republic of China. zychnu@hainanu.edu.cn.
Hainan University · CNHainan Agricultural School · CN

Funding

Hainan Province Science and Technology Special Fund ZDKJ2021016National Key Research and Development Program of China 2021YFC2600600National Natural Science Foundation of China No. 31960739Special Foundation of Agricultural and Rural Bureau of Lingao County, Hainan, China No. ZLHX2018-124R
6 · The paper itself

Abstract

backgroundCryptocaryon irritans, a common parasite in tropical and subtropical marine teleost fish, has caused serious harm to the marine aquaculture industry. Honokiol was proven to induce C. irritans tomont cytoplasm shrinkage and death in our previous study, but the mechanism by which it works remains unknown.

methodsIn this study, the changes of apoptotic morphology and apoptotic ratio were detected by microscopic observation and AnnexinV-FITC/PI staining. The effects of honokiol on intracellular calcium ([Ca

resultsThe results of the study on the effects of honokiol concentration on C. irritans tomont apoptosis-like death showed that the highest levels of prophase apoptosis-like death rate (PADR), [Ca

conclusionsThis article shows that honokiol can induce C. irritans tomont apoptosis-like death. These results suggest that honokiol may disrupt [Ca

Indexed as

ApoptosisCaspasesAllyl CompoundsAnimalsBiphenyl CompoundsCaspase 3PhenolsReactive Oxygen SpeciesRNA, MessengerAllyl CompoundsBiphenyl CompoundsCaspase 3CaspaseshonokiolPhenolsReactive Oxygen SpeciesRNA, MessengerApoptosis-like deathCryptocaryon irritansEndoplasmic reticulum stressHonokiol

Identifiers

PMID37587480
PMCPMC10428556
OpenAlexW4385874192

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.