ReviewBMC ophthalmology2023
The effects of female sex hormones on the human cornea across a woman's life cycle.
Review in BMC ophthalmology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed.
- Dual Optical Elastography Techniques Reveal the Regulation of Corneal Stiffness by Collagen XIV.Journal of biophotonics · 2026Article
- The Role of Sex in Ocular Biometry: A Large-Scale Study of Cataract Candidates in Greece.Ophthalmology and therapy · 2026Article
- Article
- Hormonal Modulation of Keratoconus: A Systematic Review and Screening Strategy for At-Risk Populations.Ophthalmology science · 2026Review
- Corneal and lens densitometry in newly diagnosed polycystic ovary syndrome patients: a quantitative analysis using pentacam HR.International ophthalmology · 2026Article
- Sex Hormones and Keratoconus: In Search of the Link.Journal of clinical medicine · 2026Article
- Molecular landscape connecting complications of dry eye disease: mechanisms, therapeutic targets, biomarkers, and future innovations.International ophthalmology · 2026Review
- Changing Epidemiology of Refractive Disorders in the Western Pacific Region, 1990-2023: Evidence From the Global Burden of Disease Study 2023.Journal of ophthalmology · 2026Article
- Sleep quality as a mediator between perceived stress and dry eye severity among Chinese nurses.Frontiers in public health · 2026Article
- Chronic Restraint Stress Misaligns Corneal Clock via β-Adrenergic and Glucocorticoid Signaling, Altering Epithelial, Neural, Immune, Metabolic States.Investigative ophthalmology & visual science · 2025Article
- Gene polymorphisms associated with corneal curvature, astigmatism and its vector components in children.Eye and vision (London, England) · 2025Article
- Progression and regression of keratoconus in an Iranian population.Scientific reports · 2025Article
- The Impact of Sex Hormones on Keratoconus.Journal of clinical medicine · 2025Review
- Comparison of Recurrent and Naïve Keratitis in a Cohort of 1303 Patients.Journal of clinical medicine · 2025Article
- Pregnancy-induced ocular changes: impacts on intraocular pressure, the cornea, and the anterior chamber.BMC ophthalmology · 2025Article
- The Effects of Surgical Androgen Deprivation Therapy for Advanced Prostate Cancer on Peripapillary Retinal Nerve Fiber Layer Thickness.The Eurasian journal of medicine · 2025Article
- Impact of myopic laser surgery and pregnancy-related hormonal fluctuations on corneal biomechanics.American journal of translational research · 2025Article
- Normative distribution of corneal epithelial thickness on 9-mm OCT maps.Frontiers in medicine · 2025Article
- Association of Di(2-ethylhexyl) Phthalate Exposure with Reproductive Hormones in the General Population and the Susceptible Population: A Systematic Review and Meta-Analysis.Environment & health (Washington, D.C.) · 2024Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cornea is a hormone-responsive tissue that responds to changing levels of female sex hormones. This review focuses on the structural and functional changes in the human cornea associated with the hormonal milestones of menarche, pregnancy, and menopause, as well as consequences stemming from the use of exogenous sex hormones for fertility control and replacement. Articles were identified by searching PubMed without language or region restrictions. The primary outcomes evaluated were changes in central corneal thickness (CCT), intraocular pressure (IOP), and quality of the ocular tear film. The potential impact of hormone-associated changes on the diagnosis and surgical management of common eye diseases, as well as the potential use of sex hormones as therapeutic agents is also considered. Understanding the physiological effects of female sex hormones on the cornea is important because that knowledge can shape the management decisions physicians and women face about ocular health across their life stages.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.