Evidence map›Paper›PMID 37587359›Full record

ReviewAnnals of surgical oncology2023

Landmark Series: The Cancer Genome Atlas and the Study of Breast Cancer Disparities.

Josh A Johnson, Brandon J Moore, Georgia Syrnioti, Claire M Eden, Drew Wright, Lisa A Newman

Abstract readComparative StudyReview
PubMed Publisher
In one paragraph

Review in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
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  9. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Josh A JohnsonDepartment of Surgery, New York Presbyterian, Weill Cornell Medicine, New York, NY, USA.
Brandon J MooreColumbia University, New York, NY, USA.
Georgia SyrniotiDepartment of Surgery, New York Presbyterian, Weill Cornell Medicine, New York, NY, USA.
Claire M EdenDepartment of Surgery, New York Presbyterian Queens, Weill Cornell Medicine, Flushing, NY, USA.
Drew WrightSamuel J. Wood Library, Weill Cornell Medicine, New York, NY, USA.
Lisa A NewmanDepartment of Surgery, New York Presbyterian, Weill Cornell Medicine, New York, NY, USA. Lan4002@med.cornell.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Race-related variation in breast cancer incidence and mortality are well-documented in the United States. The effect of genetic ancestry on disparities in tumor genomics, risk factors, treatment, and outcomes of breast cancer is less understood. The Cancer Genome Atlas (TCGA) is a publicly available resource that has allowed for the recent emergence of genome analysis research seeking to characterize tumor DNA and protein expression by ancestry as well as the social construction of race and ethnicity. Results from TCGA based studies support previous clinical evidence that demonstrates that American women with African ancestry are more likely to be afflicted with breast cancers featuring aggressive biology and poorer outcomes compared with women with other backgrounds. Data from TCGA based studies suggest that Asian women have tumors with favorable immune microenvironments and may experience better disease-free survival compared with white Americans. TCGA contains limited data on Hispanic/Latinx patients due to small sample size. Overall, TCGA provides important opportunities to define the molecular, biologic, and germline genetic factors that contribute to breast cancer disparities.

Indexed as

Breast NeoplasmsDNA, NeoplasmHealth Status DisparitiesAsianBlack or African AmericanDisease-Free SurvivalFemaleGenomicsHispanic or LatinoHumansTumor MicroenvironmentUnited StatesWhiteDNA, NeoplasmBreast cancer disparitiesCancer genomicsGenetic ancestry

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.