Evidence map›Paper›PMID 37587357›Full record

ArticleAnnals of surgical oncology2023

Characteristics Predicting Short-Term and Long-Term Health-Related Quality of Life in Patients with Esophageal Cancer After Neoadjuvant Chemoradiotherapy and Esophagectomy.

Berend J van der Wilk, Ben M Eyck, Bo J Noordman, Leonieke W Kranenburg, Mark Oppe, Sjoerd M Lagarde, Bas P L Wijnhoven, Jan J Busschbach, J Jan B van Lanschot

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In one paragraph

Article in Annals of surgical oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Berend J van der WilkDepartment of Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands. b.vanderwilk@erasmusmc.nl.ORCID http://orcid.org/0000-0002-6706-0628
Ben M EyckDepartment of Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
Bo J NoordmanDepartment of Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
Leonieke W KranenburgDepartment of Psychiatry, Section of Medical Psychology and Psychotherapy, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
Mark OppeMaths in Health, Rotterdam, The Netherlands.
Sjoerd M LagardeDepartment of Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
Bas P L WijnhovenDepartment of Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
Jan J BusschbachDepartment of Psychiatry, Section of Medical Psychology and Psychotherapy, Erasmus MC-University Medical Center, Rotterdam, The Netherlands.
J Jan B van LanschotDepartment of Surgery, Erasmus MC Cancer Institute, University Medical Center, Rotterdam, The Netherlands.
Erasmus MC Cancer Institute · NLErasmus MC · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEsophagectomy is associated with lasting effect on health-related quality of life (HRQOL). Patients desire detailed information on the expected impact of treatment on their postoperative HRQOL. The aim of the present study is to identify clinicopathological characteristics predictive for changes in short-term and long-term HRQOL after neoadjuvant chemoradiotherapy (nCRT) and surgery.

methodsHRQOL was measured using EORTC-QLQ-C30 and QLQ-OES24 questionnaires prior to nCRT, three, six, nine and twelve months postoperatively and at a minimum of six years postoperatively. Based on previous experience and available literature, several subgroups were predefined for different clinicopathological characteristics: baseline global HRQOL, WHO performance status, histology, tumor stage and tumor location. The primary endpoints of the present study were the change compared to baseline in the HRQOL dimensions physical functioning and eating problems. Secondary endpoints were global HRQOL, fatigue and emotional problems.

resultsIn total, 134 (76%) of 177 patients who received HRQOL questionnaires, responded at baseline. Patients who reported a high baseline global HRQOL had a more severe deterioration in eating problems (+14.5 to + 18.0), global HRQOL (-16.0 to -28.0) and fatigue (+10.5 to +14.9) up to six years postoperatively compared to patients who reported a low baseline global HRQOL. Patients who had stage 2 tumor (UICC 6th edition) had a more severe deterioration in eating problems (+14.6 to +19.0) and global HRQOL (-10.1 to -17.1) than patients who had stage 3 tumor.

conclusionsThe results suggest that patients with locally advanced esophageal cancer in favorable condition at baseline decline more in terms of various HRQOL outcomes.

Indexed as

Esophageal NeoplasmsQuality of LifeChemoradiotherapyEsophagectomyFatigueHumansNeoadjuvant TherapySurveys and QuestionnairesActive surveillanceEsophageal cancerHealth-related quality of lifeNeoadjuvant chemoradiotherapy

Identifiers

PMID37587357
PMCPMC10625935
OpenAlexW4385879130

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.