ArticleNature2023
Platelet factors attenuate inflammation and rescue cognition in ageing.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06451120 (Study of Platelet Rich Plasma), which is not on this map. Cited by 147 papers.
0numbers the graph read from it
0cells of the map it votes in
147citing papers in PubMed
28.5field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Study of Platelet Rich Plasma (PRP) Injections With Symptomatic Knee Osteoarthritis for Biomarker Exploration in Young and Old Human Subjects
Who cites it
147 citing papers in PubMed, 230 citations in OpenAlex.
- Infusion of young donor plasma components in older patients modifies the immune and inflammatory response to surgical tissue injury: a randomized clinical trial.Journal of translational medicine · 2025Trial
- Effects of sub-chronic cannabis smoke exposure on inflammatory markers in serum and brain in younger and older mice.Neurobiology of aging · 2026Article
- Insights Into the Role of Platelet Factor 4 in Neurodegenerative Diseases.CNS neuroscience & therapeutics · 2026Review
- Article
- Tibial bone compression promotes recovery after brain injury through osteocyte PIEZO1.Nature neuroscience · 2026Article
- Endothelial C/EBPβ/AEP pathway drives vascular deterioration and systemic aging.Science advances · 2026Article
- The Neurovascular Niche: A Gathering Venue for Neuroinflammation and Remyelination in Multiple Sclerosis.Acta physiologica (Oxford, England) · 2026Review
- Neonatal small extracellular vesicle-loaded GelNB hydrogel reprograms the vascular-immune microenvironment for spinal cord injury repair.Bioactive materials · 2026Article
- Youth-associated protein TIMP2 regulates microglial state and function in healthy and aged mice.Nature communications · 2026Article
- Stem cells as an essential mediator of the exercise-tumorigenesis link.Nature reviews. Cancer · 2026Review
- A Blood-Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN-Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Hippocampal neuroinflammation and altered peripheral neurobiological protein profile in experimental arthritis and systemic juvenile idiopathic arthritis.EBioMedicine · 2026Article
- Article
- Aged circulating CD8Immunity · 2026Article
- Microglial galectin-3 disrupts parvalbumin interneurons and hippocampal synchrony, driving cognitive deficits.Journal of neuroinflammation · 2026Article
- Exercise mimetics: molecular mechanisms, biological and therapeutic effects.Molecular biomedicine · 2026Review
- Blood serum from individuals with Alzheimer's disease alters microglial phagocytosis in vitro.Neural regeneration research · 2026Article
- Article
- Insights into the therapeutic strategies for aging and aging-associated diseases.Signal transduction and targeted therapy · 2026Review
- Ginsenoside Rg1 alleviates post-ischemic stroke neuroinflammation by inhibiting CKLF1-mediated suppression of dead/dying neuron clearance.Acta pharmaceutica Sinica. B · 2026Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 1 country.
Adam B Schroer *Department of Anatomy, University of California San Francisco, San Francisco, CA, USA. adam.schroer@ucsf.edu.ORCID 0000-0002-4038-733X
Patrick B Ventura *Department of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Juliana SucharovDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Rhea MisraDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
M K Kirsten ChuiDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Gregor BieriDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0003-0737-231X
Alana M HorowitzDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Lucas K SmithDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA.
Katriel EncaboDepartment of Urology, University of California San Francisco, San Francisco, CA, USA.
Imelda TenggaraDepartment of Urology, University of California San Francisco, San Francisco, CA, USA.
Julien CouthouisDepartment of Genetics, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-2378-4595
Joshua D GrossDepartment of Cell Biology, Duke University, Durham, NC, USA.
June M ChanDepartment of Urology, University of California San Francisco, San Francisco, CA, USA.
Anthony LukeDepartment of Orthopaedics, University of California San Francisco, San Francisco, CA, USA.
Saul A VilledaDepartment of Anatomy, University of California San Francisco, San Francisco, CA, USA. saul.villeda@ucsf.edu.ORCID 0000-0002-2726-9582
University of California, San Francisco · USDuke University · USStanford University · US
Funding
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GERMAN, MICHAEL S · 2003 to 2019
$21.8MEffect of Aerobic Exercise on Genomic Signatures of Prostate Cancer PrognosisR01CA181802 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CHAN, JUNE ML · 2014 to 2019
$3.1MSystemic Mechanisms of Brain RejuvenationR01AG077816 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SAUL A VILLEDA · 2022 to 2026
$2.7MRole of exercise-induced blood factors in rejuvenating the aged brainR01AG067740 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VILLEDA, SAUL A · 2020 to 2024
$2.0MInvestigating the role of platelets and platelet-derived factors in rejuvenation of the aged hippocampusF32AG064823 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SCHROER, ADAM · 2019 to 2022
$200kInvestigating the role of the exercise blood factor Gpld1 in restoring brain vasculature function and cognition in agingF32AG081038 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BIERI, GREGOR · 2023 to 2024
$151kNCI NIH HHS R01 CA181802NIA NIH HHS F32 AG064823NIA NIH HHS F32 AG081038NIA NIH HHS R01 AG067740NIA NIH HHS R01 AG077816NIDDK NIH HHS P30 DK063720
Abstract
Identifying therapeutics to delay, and potentially reverse, age-related cognitive decline is critical in light of the increased incidence of dementia-related disorders forecasted in the growing older population
Indexed as
AgingCognitionCognitive DysfunctionNeuroinflammatory DiseasesNootropic AgentsPlatelet Factor 4AnimalsHippocampusMaleMiceNeuronal PlasticityPlasmaReceptors, CXCR3Transcription, GeneticCxcr3 protein, mouseNootropic AgentsPlatelet Factor 4Receptors, CXCR3
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
NCT06451120ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.