ArticleNature2023
Nuclear genetic control of mtDNA copy number and heteroplasmy in humans.
Erratum issuedOpen access · hybridAbstract read
In one paragraph
Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 124 papers.
0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed
25.9field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
124 citing papers in PubMed, 166 citations in OpenAlex.
- Acute Cannabis Administration Transiently Reduces Mitochondrial DNA in Young Adults: Findings from a Secondary Analysis of a Double-Blind, Placebo-Controlled, Randomized Clinical Trial.Cannabis and cannabinoid research · 2025Trial
- Long-read sequencing enables high-accuracy mitochondrial heteroplasmy detection in Parkinson's disease.BMC genomics · 2026Article
- Inheritance and selection of the mitochondrial genome.Nature reviews. Genetics · 2026Review
- Variations in mitochondrial genome as potential prognostic markers in sickle cell disease.Haematologica · 2026Article
- Molecular Mechanisms of Obesity-Associated Oxidative Stress and Therapeutic Strategies.Antioxidants (Basel, Switzerland) · 2026Review
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- Mitophagy-mediated immune evasion: Shared strategies of pathogens.Redox biology · 2026Review
- Mitochondrial DNA homeostasis: A novel therapeutic target for neurodegenerative diseases.Neural regeneration research · 2026Article
- Understanding the somatic evolution of metabolic traits.Nature metabolism · 2026Article
- Mitochondrial stress response drives microglial senescence.Nature neuroscience · 2026Article
- Article
- Individual and joint association of maternal and cord blood mitochondrial DNA heteroplasmy and copy number with preterm birth.Pediatric research · 2026Article
- A large-scale multi-ancestry mitochondrial variant association analysis for cardiometabolic traits.Nature communications · 2026Article
- A novel approach for age estimation based on blood mitochondrial DNA analysis.International journal of legal medicine · 2026Article
- Large-scale human genomic resources drive innovations toward forensic intelligent source attribution and precision identification.International journal of legal medicine · 2026Review
- Powering the mind: deciphering the shared genetic architecture between mitochondrial DNA copy number and major psychiatric disorders.Molecular psychiatry · 2026Article
- Decoding DNA metabolism and its clinical relevance through the lens of high-throughput sequencing assays.Medical review (2021) · 2026Review
- Insights into the therapeutic strategies for aging and aging-associated diseases.Signal transduction and targeted therapy · 2026Review
- Evaluating the causal effect of mitochondrial dysfunction on Alzheimer's disease and Parkinson's disease using polygenic risk scores and Mendelian randomization.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
64 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
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Authors and funding
12 authors at 2 institutions in 2 countries.
Rahul GuptaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. rahul_gupta@hms.harvard.edu.ORCID 0000-0001-8263-2455
Masahiro KanaiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-5165-4408
Timothy J DurhamHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-2056-4199
Kristin TsuoBroad Institute of MIT and Harvard, Cambridge, MA, USA.
Jason G McCoyHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Anna V KotrysHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.ORCID 0000-0003-4983-1414
Wei ZhouBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-7719-0859
Patrick F ChinneryDepartment of Clinical Neurosciences, University of Cambridge, Cambridge, UK.
Konrad J KarczewskiBroad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-2878-4671
Sarah E CalvoHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA.
Benjamin M NealeBroad Institute of MIT and Harvard, Cambridge, MA, USA. bneale@broadinstitute.org.ORCID 0000-0003-1513-6077
Vamsi K MoothaHoward Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA. vamsi_mootha@hms.harvard.edu.ORCID 0000-0001-9924-642X
Broad Institute · USUniversity of Cambridge · GB
Funding
Technology to Empower Changes in Health (TECH) Network Participant Technologies CenterU24OD023176 · OD · SCRIPPS RESEARCH INSTITUTE, THE · PI TOPOL, ERIC JEFFREY · 2016 to 2022
$204.7MPrecision Medicine Initiative Cohort Program BiobankU24OD023121 · OD · MAYO CLINIC ROCHESTER · PI CEKANOVA, MARIA, CICEK, MINE · 2016 to 2024
$185.5MEnhancing All of Us Data Resources for Nutrition Precision Health: the All of Us Data and Research CenterU2COD023196 · OD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI GLAZER, DAVID, HARRIS, PAUL A. · 2016 to 2022
$143.7MAdaptive Platform for Personalized EngagementU24OD023163 · OD · VIGNET, INC. · PI JAIN, PRADUMAN · 2017 to 2020
$102.6MUniversity of Arizona-Banner Health All of Us Research Program OT2OD026549 · OD · UNIVERSITY OF ARIZONA · PI MORENO, FRANCISCO A, REIMAN, ERIC MICHAEL · 2018 to 2023
$78.9MCalifornia Precision Medicine Research Program ConsortiumOT2OD026552 · OD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ANTON-CULVER, HODA A, OHNO-MACHADO, LUCILA · 2018 to 2023
$73.4MAll of Us PennsylvaniaOT2OD026554 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E, VISWESWARAN, SHYAM · 2018 to 2023
$72.1MNew York City Consortium for Precision MedicineOT2OD026556 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI BIER, LOUISE E, GHARAVI, ALI G · 2018 to 2023
$67.3MSouthEast Enrollment Center (SEEC) OT2OD026551 · OD · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI CARRASQUILLO, OLVEEN, COLON, VIVIAN · 2018 to 2023
$62.8MSouthern All of Us NetworkOT2OD026548 · OD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI FOUAD, MONA N., KORF, BRUCE R · 2018 to 2023
$60.5MIllinois Precision Medicine Consortium OT2OD026557 · OD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI AHSAN, HABIBUL, ARGOS, MARIA · 2018 to 2023
$60.5MThe New England Precision Medicine Consortium of the All of Us Research ProgramOT2OD026553 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CLARK, CHERYL RENEE, KARLSON, ELIZABETH W · 2018 to 2023
$58.8MMedical Research Council MC_UU_00028/7Medical Research Council MR/S005021/1Medical Research Council MR/S035699/1NHGRI NIH HHS K99 HG012222NHGRI NIH HHS R00 HG012222NIA NIH HHS F30 AG074507NIGMS NIH HHS R35 GM122455NIGMS NIH HHS T32 GM007753NIGMS NIH HHS T32 GM144273NIH HHS OT2 OD023205NIH HHS OT2 OD023206NIH HHS OT2 OD025276NIH HHS OT2 OD025277NIH HHS OT2 OD025315NIH HHS OT2 OD025337NIH HHS OT2 OD026548NIH HHS OT2 OD026549NIH HHS OT2 OD026550NIH HHS OT2 OD026551NIH HHS OT2 OD026552NIH HHS OT2 OD026553NIH HHS OT2 OD026554NIH HHS OT2 OD026555NIH HHS OT2 OD026556NIH HHS OT2 OD026557NIH HHS U24 OD023121NIH HHS U24 OD023163NIH HHS U24 OD023176NIH HHS U2C OD023196NIMH NIH HHS R01 MH101244NIMH NIH HHS R37 MH107649Wellcome Trust
Abstract
Mitochondrial DNA (mtDNA) is a maternally inherited, high-copy-number genome required for oxidative phosphorylation
Indexed as
Cell NucleusDNA Copy Number VariationsDNA, MitochondrialHeteroplasmyMitochondriaAgedAllelesGenome-Wide Association StudyG-QuadruplexesHumansINDEL MutationPolymorphism, Single NucleotideDNA, Mitochondrial
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