Evidence map›Paper›PMID 37587336›Full record

ArticleNature2023

Transient naive reprogramming corrects hiPS cells functionally and epigenetically.

Sam Buckberry, Xiaodong Liu, Daniel Poppe, Jia Ping Tan, Guizhi Sun, Joseph Chen, Trung Viet Nguyen, Alex de Mendoza, Jahnvi Pflueger, Thomas Frazer and 14 more

Open access · hybridAbstract read
In one paragraph

Article in Nature, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
11.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 77 citations in OpenAlex.

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  16. Challenges and opportunities of human iPSC-derived NK as "Off-the-shelf" cellular therapies.Journal of experimental & clinical cancer research : CR · 2025
    Review
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  19. Harnessing Intelligence from Brain Cells In Vitro.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2025
    Review
  20. The Rise of Mechanobiology for Advanced Cell Engineering and Manufacturing.Advanced materials (Deerfield Beach, Fla.) · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 8 institutions in 5 countries.

Sam Buckberry *Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0003-2388-6046
Xiaodong Liu *Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0002-9315-3406
Daniel Poppe *Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-6674-8420
Jia Ping Tan *Department of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.
Guizhi SunDepartment of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.
Joseph ChenDepartment of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.
Trung Viet NguyenHarry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.
Alex de MendozaHarry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-6441-6529
Jahnvi PfluegerHarry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.
Thomas FrazerHarry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.
Dulce B Vargas-LandínHarry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia.ORCID 0000-0002-4773-9406
Jacob M PaynterDepartment of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.
Nathan SmitsMater Research Institute, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0002-0156-5076
Ning LiuSouth Australian Health and Medical Research Institute, Adelaide, South Australia, Australia.
John F OuyangProgram in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID 0000-0002-1239-1577
Fernando J RosselloDepartment of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.
Hun S ChyAustralian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.
Owen J L RackhamProgram in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Medical School, Singapore, Singapore.ORCID 0000-0002-4390-0872
Andrew L LaslettAustralian Regenerative Medicine Institute, Monash University, Melbourne, Victoria, Australia.
James BreenJohn Curtin School of Medical Research, College of Health and Medicine, Australian National University, Canberra, Australian Capital Territory, Australia.
Geoffrey J FaulknerMater Research Institute, University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0001-5769-4494
Christian M NefzgerDepartment of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0003-4631-5633
Jose M PoloDepartment of Anatomy and Developmental Biology, Monash University, Melbourne, Victoria, Australia. jose.polo@monash.edu.ORCID 0000-0002-2531-778X
Ryan ListerHarry Perkins Institute of Medical Research, QEII Medical Centre and Centre for Medical Research, The University of Western Australia, Perth, Western Australia, Australia. ryan.lister@uwa.edu.au.ORCID 0000-0001-6637-7239
Discovery Institute · USThe University of Western Australia · AUThe University of Queensland · AUAustralian National University · AUAustralian Regenerative Medicine Institute · AUNational University of Singapore · SGQueen Mary University of London · GBSouth Australian Health and Medical Research Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cells undergo a major epigenome reconfiguration when reprogrammed to human induced pluripotent stem cells (hiPS cells). However, the epigenomes of hiPS cells and human embryonic stem (hES) cells differ significantly, which affects hiPS cell function

Indexed as

Cellular ReprogrammingEpigenesis, GeneticInduced Pluripotent Stem CellsChromatinDNA DemethylationDNA MethylationDNA Transposable ElementsHuman Embryonic Stem CellsHumansLamin Type BChromatinDNA Transposable ElementsLamin Type B

Identifiers

PMID37587336
PMCPMC10447250
OpenAlexW4385879204

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.