Evidence map›Paper›PMID 37587235›Full record

ArticleScientific reports2023

Modeling and optimization of parallelized immunomagnetic nanopore sorting for surface marker specific isolation of extracellular vesicles from complex media.

Andrew A Lin, Hanfei Shen, Griffin Spychalski, Erica L Carpenter, David Issadore

Abstract read
In one paragraph

Article in Scientific reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Andrew A LinDepartment of Bioengineering, University of Pennsylvania, 210 S. 33rd St., Philadelphia, PA, 19104, USA.
Hanfei ShenDepartment of Bioengineering, University of Pennsylvania, 210 S. 33rd St., Philadelphia, PA, 19104, USA.
Griffin SpychalskiDepartment of Bioengineering, University of Pennsylvania, 210 S. 33rd St., Philadelphia, PA, 19104, USA.
Erica L CarpenterPerelman School of Medicine, University of Pennsylvania, 3400 Civic Center Blvd., Philadelphia, PA, 19104, USA.
David IssadoreDepartment of Bioengineering, University of Pennsylvania, 210 S. 33rd St., Philadelphia, PA, 19104, USA. issadore@seas.upenn.edu.

Funding

Center for Sub-Cellular GenomicsRM1HG010023 · NHGRI · UNIVERSITY OF PENNSYLVANIA · PI EBERWINE, JAMES H, KIM, JUNHYONG · 2018 to 2022
$11.0M
Nanomagnetic isolation and sensing for mobile HIV-1 self-testingR33AI147406 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI ISSADORE, DAVID AARON · 2022 to 2023
$1.6M
High Throughput Digital Droplet ELISA for Ultrasensitive Multiplexed DiagnosticsR21CA236653 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ISSADORE, DAVID AARON · 2020 to 2022
$578k
A nanomagnetic platform technology to characterize traumatic brain injury using brain derived extracellular vesiclesR21MH118170 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI ISSADORE, DAVID AARON · 2018 to 2019
$414k
NCI NIH HHS R21 CA236653NCI NIH HHS R21CA236653NHGRI NIH HHS RM1 HG010023NIAID NIH HHS R33 AI147406NIH HHS RM1HG010023NIMH NIH HHS R21 MH118170NIMH NIH HHS R21MH118170
6 · The paper itself

Abstract

The isolation of specific subpopulations of extracellular vesicles (EVs) based on their expression of surface markers poses a significant challenge due to their nanoscale size (< 800 nm), their heterogeneous surface marker expression, and the vast number of background EVs present in clinical specimens (10

Indexed as

Extracellular VesiclesLiver NeoplasmsNanoporesCell MovementComputer SimulationHumans

Identifiers

PMID37587235
PMCPMC10432479

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.