Evidence map›Paper›PMID 37587231›Full record

ArticleNature aging2023

Platelet factors are induced by longevity factor klotho and enhance cognition in young and aging mice.

Cana Park, Oliver Hahn, Shweta Gupta, Arturo J Moreno, Francesca Marino, Blen Kedir, Dan Wang, Saul A Villeda, Tony Wyss-Coray, Dena B Dubal

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature aging, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
77citing papers in PubMed, 1 pooled it
29.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

77 citing papers in PubMed, 1 synthesis or guideline pooled it, 119 citations in OpenAlex.

  1. Pooled it
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  18. Senescence of T cells and organ aging.Inflammation and regeneration · 2026
    Review
  19. Article
  20. Research progress on blood therapy for anti-aging.Journal of advanced research · 2026
    Review

17 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Cana ParkDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Oliver HahnDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
Shweta GuptaDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Arturo J MorenoDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Francesca MarinoDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Blen KedirDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-1654-2149
Dan WangDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA.
Saul A VilledaDepartment of Anatomy, University of California, San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-2726-9582
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-5893-0831
Dena B DubalDepartment of Neurology and Weill Institute for Neurosciences, University of California, San Francisco, CA, USA. Dena.dubal@ucsf.edu.ORCID http://orcid.org/0000-0001-7504-4372
University of California, San Francisco · USStanford University · USNeurosciences Institute · US

Funding

Clinical and Translational Science InstituteUL1TR001872 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI COLLARD, HAROLD R, JACOBY, VANESSA · 2016 to 2025
$112.1M
Mechanisms of X-Chromosome-dependent Sex Difference inAlzheimers DiseaseRF1AG068325 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2020 to 2020
$2.3M
Klotho and Neurodegenerative DiseaseR01NS092918 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2016 to 2020
$1.7M
Mechanisms of X-Chromosome-dependent Sex Difference inAlzheimers DiseaseR01AG068325 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI DUBAL, DENA BOU · 2024 to 2024
$526k
NCATS NIH HHS UL1 TR001872NIA NIH HHS R01 AG068325NIA NIH HHS RF1 AG068325NINDS NIH HHS R01 NS092918
6 · The paper itself

Abstract

Platelet factors regulate wound healing and can signal from the blood to the brain

Indexed as

AgingLongevityAnimalsBlood Coagulation FactorsCognitionKlotho ProteinsMicePlatelet Factor 4Blood Coagulation FactorsKlotho ProteinsKl protein, mousePlatelet Factor 4

Identifiers

PMID37587231
PMCPMC10501899
OpenAlexW4385879071

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.