ArticleNature communications2023
Genome-wide association studies reveal novel loci associated with pyrethroid and organophosphate resistance in Anopheles gambiae and Anopheles coluzzii.
Article in Nature communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers.
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Who cites it
57 citing papers in PubMed, 89 citations in OpenAlex.
- Intersecting experimental evolution and CRISPR screens to identify novel toxin resistance loci.eLife · 2026Article
- Comparative genomics of nicotinic acetylcholine receptors reveals early divergence of the α6 subunit in cryptic Anopheles species.BMC genomics · 2026Article
- Multi-omics analysis identifies loci associated with pyrethroid resistance across sister species in the Anopheles gambiae species complex.BMC genomics · 2026Article
- Larval habitat drives differential selection pressures on genetic insecticide resistance and metabolic enzyme plasticity in Anopheles gambiae s.l during laboratory colonization.Scientific reports · 2026Article
- Impact of indoor residual spraying and insecticide-treated nets on malaria burden in 8 districts in West Nile and Acholi regions, Uganda: a quasi-experimental study.BMC global and public health · 2026Article
- Discovery of two novel mutations, R52H and N868D, in the voltage-gated sodium channel of Aedes aegypti associated with pyrethroid resistance.PLoS neglected tropical diseases · 2026Article
- Genotype by environmental interactions shape insecticide resistance phenotypes in Culex pipiens and Culex restuans.Heredity · 2026Article
- Widespread pyrethroid resistance and high kdr L995F allele frequencies in Anopheles gambiae sensu lato populations from Southern Benin, West Africa.Tropical medicine and health · 2026Article
- Genomic Signatures of Microgeographic Adaptation in Anopheles coluzzii Across Urban, Rural, and Forested Environments in Gabon.Molecular ecology · 2026Article
- Vietnamese Odonata: bridging global biodiversity, ecological, and conservation gaps in a changing world.npj biodiversity · 2026Review
- Knockdown resistance (kdr) mutations in the Japanese encephalitis virus vector Culex tritaeniorhynchus from the Republic of Korea.Tropical medicine and health · 2026Article
- The genomics of insecticide resistance in Anopheles funestus: insights from a large bed-net trial.BMC genomics · 2026Article
- Genetic Surveillance Reveals Differential Evolutionary Dynamic of Anopheles gambiae Under Contrasting Insecticidal Tools Used in Malaria Control.Molecular ecology · 2026Article
- Spatial and temporal signatures of genomic insecticide resistance in the Anopheles arabiensis mosquito malaria vector from Ethiopia.Research square · 2026Article
- Advances in haplotype phasing and genotype imputation.Nature reviews. Genetics · 2026Review
- Genomic population structure and insecticide resistance mechanisms in the malaria vector An. coluzzii across contrasting bioclimatic zones in West Africa.BMC genomics · 2026Article
- PoolSeq Genome-Wide Association Studies and Microbial Signature Analyses Identify Novel Candidates Associated With Pyrethroid Resistance Evolution in Anopheles funestus in Cameroon.Molecular ecology · 2026Article
- Standing genetic variation underlies divergence of nicotinic acetylcholine receptor subunits among cryptic species of thebioRxiv : the preprint server for biology · 2025Article
- A genomic toolkit for surveillance and elimination of the principal malaria vectors in Southeast Asia.bioRxiv : the preprint server for biology · 2025Article
- Genome-wide analysis of genetic diversity in Anopheles darlingi from Rondônia State, Brazil.Communications biology · 2025Article
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22 authors at 8 institutions in 6 countries.
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Abstract
Resistance to insecticides in Anopheles mosquitoes threatens the effectiveness of malaria control, but the genetics of resistance are only partially understood. We performed a large scale multi-country genome-wide association study of resistance to two widely used insecticides: deltamethrin and pirimiphos-methyl, using sequencing data from An. gambiae and An. coluzzii from ten locations in West Africa. Resistance was highly multi-genic, multi-allelic and variable between populations. While the strongest and most consistent association with deltamethrin resistance came from Cyp6aa1, this was based on several independent copy number variants (CNVs) in An. coluzzii, and on a non-CNV haplotype in An. gambiae. For pirimiphos-methyl, signals included Ace1, cytochrome P450s, glutathione S-transferases and the nAChR target site of neonicotinoid insecticides. The regions around Cyp9k1 and the Tep family of immune genes showed evidence of cross-resistance to both insecticides. These locally-varying, multi-allelic patterns highlight the challenges involved in genomic monitoring of resistance, and may form the basis for improved surveillance methods.
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