ArticleZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences2023
High expression of VARS promotes the growth of multiple myeloma cells by causing imbalance in valine metabolism.
Article in Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 3 citations in OpenAlex.
- Unveiling VARS1: a key driver of colorectal cancer progression and immune modulation.International journal of clinical oncology · 2026Article
- RARS1 inhibits ENO1 ubiquitination and degradation to protect against ferroptosis in hepatocellular carcinoma.Frontiers in immunology · 2025Article
- Anti-tumor potential of high salt in breast Cancer cell lines.Molecular biology reports · 2024Article
- Causal effects of genetically determined blood metabolites on multiple myeloma: a Mendelian randomization study.Scientific reports · 2023Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
objectivesMultiple myeloma (MM) is a plasma cell malignancy occurring in middle and old age. MM is still an incurable disease due to its frequent recurrence and drug resistance. However, its pathogenesis is still unclear. Abnormal amino acid metabolism is one of the important characteristics of MM, and the important metabolic pathway of amino acids participates in protein synthesis as basic raw materials. Aminoacyl transfer ribonucleic acid synthetase (
methodsThe corresponding gene number was combined with the gene expression profile GSE5900 dataset and GSE2658 dataset in Gene Expression Omnibus (GEO) database to standardize the gene expression data of
resultsGene enrichment analysis showed that tRNA processing related genes were significantly enriched in MM compared with HD (
conclusionsMM patients with abnormal high expression of VARS have a poor prognosis. VARS promotes the malignant growth of MM cells by affecting the regulation of valine metabolism.
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Registered trials
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