Evidence map›Paper›PMID 37587057›Full record

ArticleInternal medicine (Tokyo, Japan)2023

Management of Acquired Factor X Deficiency Caused by In Vitro Non-neutralizing Anti-factor X Autoantibodies with Pre-emptive Corticosteroid Therapy.

Akio Onishi, Yuji Shimura, Takahisa Nakamura, Masayoshi Souri, Tsukasa Osaki, Shinsuke Mizutani, Taku Tsukamoto, Tsutomu Kobayashi, Akitada Ichinose, Junya Kuroda

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Akio OnishiDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Yuji ShimuraDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Takahisa NakamuraDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Masayoshi SouriDepartment of Molecular Patho-Biochemistry and Patho-Biology, Yamagata University School of Medicine, Japan.
Tsukasa OsakiDepartment of Molecular Patho-Biochemistry and Patho-Biology, Yamagata University School of Medicine, Japan.
Shinsuke MizutaniDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Taku TsukamotoDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Tsutomu KobayashiDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Akitada IchinoseDepartment of Molecular Patho-Biochemistry and Patho-Biology, Yamagata University School of Medicine, Japan.
Junya KurodaDivision of Hematology and Oncology, Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Kyoto Prefectural University of Medicine · JPMinistry of Health Labour and Welfare · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Coagulation factor X (FX) deficiency causes severe hemorrhagic symptoms. We herein report a 90-year-old man with hemorrhagic symptoms and prolongation of prothrombin time (PT) and activated partial thromboplastin time (APTT). Cross-mixing tests showed a factor deficiency pattern, but administration of plasma products was not effective. Acquired coagulation factor deficiency was suspected, and immunosuppressive therapy was started. After the intervention, his hemorrhagic symptoms improved. A decrease in FX activity was later confirmed, and anti-FX autoantibody was retrospectively detected by an enzyme-linked immunosorbent assay. Immediate intervention is important for patients suspected of having acquired coagulation factor deficiency.

Indexed as

Factor X DeficiencyAdrenal Cortex HormonesAged, 80 and overAutoantibodiesBlood Coagulation FactorsHumansMaleRetrospective StudiesAdrenal Cortex HormonesAutoantibodiesBlood Coagulation Factorsacquired hemophiliacorticosteroidfactor X deficiency

Identifiers

PMID37587057
PMCPMC10484778
OpenAlexW4385803561

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.