Evidence map›Paper›PMID 37586881›Full record

ArticleNeurology2023

Eligibility for Anti-Amyloid Treatment in a Population-Based Study of Cognitive Aging.

Rioghna R Pittock, Jeremiah A Aakre, Anna M Castillo, Vijay K Ramanan, Walter K Kremers, Clifford R Jack, Prashanthi Vemuri, Val J Lowe, David S Knopman, Ronald C Petersen and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed, 4 pooled it
28.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

98 citing papers in PubMed, 4 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Eligibility for donanemab trial in a population-based study of cognitive aging.The journal of prevention of Alzheimer's disease · 2025
    Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Eligibility of men vs. women in Alzheimer's trials: Inclusive vs. representative.The journal of prevention of Alzheimer's disease · 2026
    Article
  14. Beyond the Cochrane review: Re-evaluating anti-amyloid therapy in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  15. Study partner profile effects on CDR-SB change in anti-amyloid therapy evaluation.medRxiv : the preprint server for health sciences · 2026
    Article
  16. Review
  17. Review
  18. Article
  19. Long-term treatment of early Alzheimer's disease with donanemab.The journal of prevention of Alzheimer's disease · 2026
    Article
  20. Observational

38 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Rioghna R PittockFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.ORCID https://orcid.org/0009-0006-2519-9476
Jeremiah A AakreFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.
Anna M CastilloFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.ORCID https://orcid.org/0009-0004-2037-7646
Vijay K RamananFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.ORCID https://orcid.org/0000-0001-6591-8734
Walter K KremersFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.
Clifford R JackFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.ORCID https://orcid.org/0000-0001-7916-622X
Prashanthi VemuriFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.
Val J LoweFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.
David S KnopmanFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.
Ronald C PetersenFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.ORCID https://orcid.org/0000-0002-8178-6601
Jonathan Graff-RadfordFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN.
Maria VassilakiFrom the Department of Neurology (R.R.P., V.K.R., D.S.K., R.C.P., J.G.-R.), Mayo Clinic, Rochester, MN; The College (R.R.P.), University of Chicago, IL; Departments of Quantitative Health Sciences (J.A.A., A.M.C., W.K.K., R.C.P., M.V.) and Radiology (C.R.J., P.V., V.J.L.), Mayo Clinic, Rochester, MN. vassilaki.maria@mayo.edu.ORCID https://orcid.org/0000-0001-8328-136X
Mayo Clinic · US

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI Walter K. Kremers · 2019 to 2026
$33.5M
Disease pathways in the population determined by amyloid, tau, and neurodegeneration imaging biomarkersR37AG011378 · NIA · MAYO CLINIC ROCHESTER · PI CLIFFORD R. JACK · 2018 to 2026
$6.8M
Validating the New Criteria for Preclinical Alzheimer's diseaseR01AG041851 · NIA · MAYO CLINIC ROCHESTER · PI JACK, CLIFFORD R., KNOPMAN, DAVID S · 2012 to 2021
$6.3M
Development, Validation, and Application of an Imaging based CVD ScaleR01NS097495 · NINDS · MAYO CLINIC ROCHESTER · PI VEMURI, PRASHANTHI · 2016 to 2020
$2.9M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR33AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2020 to 2022
$2.4M
Interdisciplinary Infrastructure for Aging Research: Rochester Epidemiology ProjectR21AG058738 · NIA · MAYO CLINIC ROCHESTER · PI LEBRASSEUR, NATHAN K, OLSON, JANET E · 2018 to 2019
$437k
NIA NIH HHS P30 AG062677NIA NIH HHS R01 AG041851NIA NIH HHS R21 AG058738NIA NIH HHS R33 AG058738NIA NIH HHS R37 AG011378NIA NIH HHS U01 AG006786NINDS NIH HHS R01 NS097495
6 · The paper itself

Abstract

BACKGROUND AND

objectivesTreatment options for Alzheimer disease (AD) are limited and have focused mainly on symptomatic therapy and improving quality of life. Recently, lecanemab, an anti-β-amyloid monoclonal antibody (mAb), received accelerated approval by the US Food and Drug Administration for treatment in the early stages of biomarker-confirmed symptomatic AD. An additional anti-β-amyloid mAb, aducanumab, was approved in 2021, and more will potentially become available in the near future. Research on the applicability and generalizability of the anti-β-amyloid mAb eligibility criteria on adults with biomarkers available in the general population has been lacking. The study's primary aim was to apply the clinical trial eligibility criteria for lecanemab treatment to participants with early AD of the population-based Mayo Clinic Study of Aging (MCSA) and assess the generalizability of anti-amyloid treatment. The secondary aim of this study was to apply the clinical trial eligibility criteria for aducanumab treatment in MCSA participants.

methodsThis cross-sectional study aimed to apply the clinical trial eligibility criteria for lecanemab and aducanumab treatment to participants with early AD of the population-based MCSA and assess the generalizability of anti-amyloid treatment.

resultsTwo hundred thirty-seven MCSA participants (mean age [SD] 80.9 [6.3] years, 54.9% male, and 97.5% White) with mild cognitive impairment (MCI) or mild dementia and increased brain amyloid burden by PiB PET comprised the study sample. Lecanemab trial's inclusion criteria reduced the study sample to 112 (47.3% of 237) participants. The trial's exclusion criteria further narrowed the number of potentially eligible participants to 19 (overall 8% of 237). Modifying the eligibility criteria to include all participants with MCI (instead of applying additional cognitive criteria) resulted in 17.4% of participants with MCI being eligible for lecanemab treatment. One hundred four participants (43.9% of 237) fulfilled the aducanumab clinical trial's inclusion criteria. The aducanumab trial's exclusion criteria further reduced the number of available participants, narrowing those eligible to 12 (5.1% of 237). Common exclusions were related to other chronic conditions and neuroimaging findings. DISCUSSION: Findings estimate the limited eligibility in typical older adults with cognitive impairment for anti-β-amyloid mAbs.

Indexed as

Alzheimer DiseaseCognitive AgingCognitive DysfunctionAgedAmyloidAmyloid beta-PeptidesChildCross-Sectional StudiesFemaleHumansMaleQuality of LifeAmyloidAmyloid beta-Peptides

Identifiers

PMID37586881
PMCPMC10663008
OpenAlexW4385854855

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.