Evidence map›Paper›PMID 37586809›Full record

Observational studyThe Korean journal of internal medicine2023

Prognostic role of the neutrophil-to-lymphocyte ratio in patients with chronic kidney disease.

Jin Kim, Su Hyun Song, Tae Ryom Oh, Sang Heon Suh, Hong Sang Choi, Chang Seong Kim, Seong Kwon Ma, Soo Wan Kim, Eun Hui Bae

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in The Korean journal of internal medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
7.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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  18. Kidney transplantation in the elderly.The Korean journal of internal medicine · 2024
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jin KimDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Su Hyun SongDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Tae Ryom OhDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Sang Heon SuhDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Hong Sang ChoiDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Chang Seong KimDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Seong Kwon MaDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Soo Wan KimDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Eun Hui BaeDepartment of Internal Medicine, Chonnam National University Medical School, Gwangju, Korea.
Chonnam National University · KR

Funding

Chonnam National University Hospital Biomedical Research Institute BCRI22040Ministry of Science and ICTNational Research Foundation of Korea 2019R1A2C1003971
6 · The paper itself

Abstract

BACKGROUND/

aimsThe neutrophil-to-lymphocyte ratio (NLR) has a prognostic value in cardiovascular disease, infection, inflammatory disease, and several malignancies. Therefore, the NLR has a possible predictive value in patients with chronic kidney disease (CKD), but this predictive value has not been validated. Here, we aimed to investigate the possibility of NLR as a predictor of CKD progression.

methodsThis retrospective observational study included 141 patients with non-dialysis CKD. The participants were divided into terciles (T1, T2, and T3) according to NLR. The primary outcome was defined as a composite kidney event, which included a decline in the estimated glomerular filtration rate (eGFR) of at least 50% or initiation of renal replacement therapy during the follow-up period.

resultsThe mean follow-up duration was 5.45 ± 2.11 years. The mean NLRs were 1.35 ± 0.05 in T1 (n = 47), 2.16 ± 0.04 in T2 (n = 47), and 4.29 ± 0.73 in T3 (n = 47). The group with the highest NLR (T3) had higher baseline CKD and serum creatinine and lower eGFR levels than the group with the lowest NLR (T1). The cumulative incidence rate of composite kidney events was significantly higher in T3 compared with T1 (p < 0.001, log-rank test). Cox regression analysis revealed that high NLR was associated with the risk of composite kidney events (adjusted hazard ratio, 3.33; 95% confidence interval, 1.43-7.76).

conclusionA higher NLR reflects the more advanced stage of CKD and suggests a role for NLR as a biomarker for predicting CKD progression.

Indexed as

NeutrophilsRenal Insufficiency, ChronicHumansKidneyLymphocytesPrognosisChronic kidney diseaseEstimated glomerular filtration rateNeutrophil-to-lymphocyte ratio

Identifiers

PMID37586809
PMCPMC10493449
OpenAlexW4385855732

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.