Evidence map›Paper›PMID 37586749›Full record

ArticleMolecular pharmacology2023

Substituted Cysteine Modification and Protection with n-Alkyl-MTS Reagents Quantifies Steric Changes Induced by a Mutation in Anesthetic Binding Sites on GABA Type A Receptors.

Kieran Bhave, Stuart A Forman

Open access · bronzeAbstract read
In one paragraph

Article in Molecular pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 72% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kieran BhaveBeecher-Mallinckrodt Laboratories, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts.
Stuart A FormanBeecher-Mallinckrodt Laboratories, Department of Anesthesia Critical Care and Pain Medicine, Massachusetts General Hospital, Boston, Massachusetts saforman@mgh.harvard.edu.ORCID 0000-0001-6340-2478
Massachusetts General Hospital · US

Funding

Basic and Translational Research on General AnestheticsR35GM141951 · NIGMS · MASSACHUSETTS GENERAL HOSPITAL · PI FORMAN, STUART A · 2021 to 2025
$3.3M
NIGMS NIH HHS R35 GM141951
6 · The paper itself

Abstract

Multiple approaches, including cryogenic electron microscopy (cryo-EM), indicate that the anesthetics etomidate and propofol modulate

Indexed as

AnestheticsEtomidatePropofolBinding SitesCysteinegamma-Aminobutyric AcidMesylatesMutationReceptors, GABA-AAnestheticsCysteineEtomidategamma-Aminobutyric AcidMesylatesmethanethiosulfonatePropofolReceptors, GABA-A

Identifiers

PMID37586749
PMCPMC10658906
OpenAlexW4385879027

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.