Evidence map›Paper›PMID 37586535›Full record

ArticleThe Science of the total environment2023

Unraveling the in vivo fate of inhaled micro- and nanoplastics with PET imaging.

Samantha Delaney, Cindy Rodriguez, Samantha M Sarrett, Eric J Dayts, Brian M Zeglis, Outi Keinänen

Open access · hybridAbstract read
In one paragraph

Article in The Science of the total environment, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. In Vivo Microplastic Detection With Photoacoustic Imaging.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Tracking of [Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. ComparativeDalton transactions (Cambridge, England : 2003) · 2025
    Article
  14. Article
  15. Article
  16. Biological Effects of Micro-/Nano-Plastics in Macrophages.Nanomaterials (Basel, Switzerland) · 2025
    Review
  17. Microplastics in Agricultural Crops and Their Possible Impact on Farmers' Health: A Review.International journal of environmental research and public health · 2024
    Review
  18. Article
  19. Article
  20. Good practices forEJNMMI radiopharmacy and chemistry · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 2 countries.

Samantha DelaneyDepartment of Chemistry, Hunter College of the City University of New York, New York, NY 10065, USA; Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
Cindy RodriguezDepartment of Chemistry, Hunter College of the City University of New York, New York, NY 10065, USA; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA.
Samantha M SarrettDepartment of Chemistry, Hunter College of the City University of New York, New York, NY 10065, USA; Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA.
Eric J DaytsDepartment of Chemistry, Hunter College of the City University of New York, New York, NY 10065, USA.
Brian M ZeglisDepartment of Chemistry, Hunter College of the City University of New York, New York, NY 10065, USA; Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA; Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10021, USA; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA; Department of Radiology, Weill Cornell Medical College, New York, NY 10021, USA.
Outi KeinänenDepartment of Chemistry, Hunter College of the City University of New York, New York, NY 10065, USA; Ph.D. Program in Biochemistry, The Graduate Center of the City University of New York, New York, NY 10016, USA; Department of Chemistry, University of Helsinki, Helsinki 00014, Finland. Electronic address: omk2009@med.cornell.edu.
The Graduate Center, CUNY · USCity University of New York · USHunter College · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
The Clinical PET Imaging of Metastatic Breast Cancer with Site-Specifically Labeled 89Zr-TrastuzumabR01CA204167 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI LEWIS, JASON S., ULANER, GARY ALLAN · 2016 to 2020
$3.4M
Novel Transgenic Mouse Models Addressing Outstanding Translational Barriers in Antibody-Based TherapeuticsR01CA244327 · NCI · ROCKEFELLER UNIVERSITY · PI BOURNAZOS, STYLIANOS · 2020 to 2024
$3.0M
Novel Reagents for Rapid and Stable Thiol-Based BioconjugationsR01CA240963 · NCI · HUNTER COLLEGE · PI ZEGLIS, BRIAN MATTHEW · 2019 to 2023
$1.6M
Harnessing PET to Study the In Vivo Fate and Health Effects of Micro- and NanoplasticsR00ES034053 · NIEHS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI KEINAENEN, OUTI MARIA · 2023 to 2025
$747k
The Ivis Spectrum CT for Pre-Clinical Oncology ResearchS10OD016207 · OD · SLOAN-KETTERING INST CAN RESEARCH · PI ZANZONICO, PAT B · 2013 to 2013
$595k
SHARED INSTRUMENT: FOCUS MICROPET: CANCERS10RR020892 · NCRR · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LARSON, STEVEN MARK · 2005 to 2005
$499k
Harnessing PET to Study the In Vivo Fate and Health Effects of Micro- and NanoplasticsK99ES034053 · NIEHS · HUNTER COLLEGE · PI KEINAENEN, OUTI MARIA · 2022 to 2022
$111k
Leveraging Metalloinsertors for the PET Imaging and Endoradiotherapy of MMR-Deficient CancersF31CA275334 · NCI · HUNTER COLLEGE · PI DELANEY, SAMANTHA PATRICIA · 2022 to 2023
$65k
NCI NIH HHS F31 CA275334NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204167NCI NIH HHS R01 CA240963NCI NIH HHS R01 CA244327NCRR NIH HHS S10 RR020892NIEHS NIH HHS K99 ES034053NIEHS NIH HHS R00 ES034053NIH HHS S10 OD016207
6 · The paper itself

Abstract

Microplastics and nanoplastics have become ubiquitous environmental pollutants. The threat these plastics pose to human health has fueled research focused on their pathophysiology and toxicology, yet many of their fundamental properties - for example, their in vivo pharmacokinetics - remain poorly understood. In this investigation, we have harnessed positron emission tomography (PET) to track the in vivo fate of micro- and nanoplastics administered to mice intratracheally and intravenously. To this end, 1 μm and 20 nm diameter amine-functionalized polystyrene particles were modified with an isothiocyanate-bearing variant of desferrioxamine (DFO) and radiolabeled with the positron-emitting radiometal [

Indexed as

Environmental PollutantsRadioisotopesAnimalsCell Line, TumorDeferoxamineHumansMiceMicroplasticsPlasticsPositron-Emission TomographyTissue DistributionZirconiumDeferoxamineEnvironmental PollutantsMicroplasticsPlasticsRadioisotopesZirconiumMicroplasticsNanoplasticsPositron emission tomographyPulmonary exposureZirconium-89

Identifiers

PMID37586535
PMCPMC10841220
OpenAlexW4385799617

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.