ArticleCell reports. Medicine2023
Boosting NAD preferentially blunts Th17 inflammation via arginine biosynthesis and redox control in healthy and psoriasis subjects.
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Article in Cell reports. Medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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0cells of the map it votes in
24citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 23 citations in OpenAlex.
- NAD+ augmentation by nicotinamide riboside engages SLIT2/ROBO1 signaling to attenuate Th17 inflammation in psoriasis.JCI insight · 2026Trial
- Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double-Blind Randomized Crossover Placebo-Controlled Trial.Aging cell · 2025Trial
- Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1-FOXO1 Signaling to Enhance ILC3s Effector Function.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Nicotinamide riboside enhances adoptive T cell therapy by promoting memory differentiation and metabolic fitness.Molecular therapy : the journal of the American Society of Gene Therapy · 2026Article
- SIRT5-dependent regulation of ASL controls arginine metabolism and T cell function.bioRxiv : the preprint server for biology · 2026Article
- Epidermal NAD+ deficiency induces IL-36-mediated skin inflammation and acanthosis.JCI insight · 2026Article
- Nutrition's role in extending healthspan: CRN-international symposium report.European journal of nutrition · 2026Article
- Cytoplasmic NAD/H synthesis via NRK1 regulates inflammatory capacity and promotes survival of CD4Nature communications · 2026Article
- Exploring key genes in NAFLD linked to glutamine metabolism: A comprehensive analysis combining multi-omics, machine learning and SHAP.Asia Pacific journal of clinical nutrition · 2026Article
- RestorinDrug design, development and therapy · 2026Article
- Review
- Inhibition of bruton's tyrosine kinase directly alleviates pathogenic CD4+ T cell response via PPAR-γ signaling in autoimmune uveitis.Journal of neuroinflammation · 2025Article
- Effects of Acute Time-Restricted Eating on Inflammation in Individuals With Psoriasis: Protocol for a Case-Control, Prospective Study.JMIR research protocols · 2025Article
- NAD + metabolism and function in innate and adaptive immune cells.Journal of inflammation (London, England) · 2025Review
- Nicotinamide riboside alleviates ionizing radiation-induced intestinal senescence by alleviating oxidative damage and regulating intestinal metabolism.Journal of advanced research · 2025Article
- Gut Microbes as the Major Drivers of Rheumatoid Arthritis: Our Microbes Are Our Fortune!Microorganisms · 2025Review
- Mitochondrial fatty acid oxidation regulates monocytic type I interferon signaling via histone acetylation.Science advances · 2025Article
- Article
- Regulation of and challenges in targeting NADNature reviews. Molecular cell biology · 2024Review
- Gut microbiota as a sensor of autoimmune response and treatment for rheumatoid arthritis.Immunological reviews · 2024Review
Corrections and comments
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Authors and funding
14 authors at 6 institutions in 3 countries.
Kim HanLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Komudi SinghLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Allison M MeadowsLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK.
Rahul SharmaLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Shahin HassanzadehLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Jing WuLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Haley Goss-HolmesLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA.
Rebecca D HuffstutlerCardiovascular Branch, NHLBI, NIH, Bethesda, MD, USA.
Heather L TeagueLaboratory of Cardiometabolic Disease and Inflammation, NHLBI, NIH, Bethesda, MD, USA.
Nehal N MehtaLaboratory of Cardiometabolic Disease and Inflammation, NHLBI, NIH, Bethesda, MD, USA.
Julian L GriffinDepartment of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK; The Rowett Institute, School of Medicine, Medical Sciences and Nutrition, Foresterhill Campus, Aberdeen, UK.
Rong TianMitochondria and Metabolism Center, Department of Anesthesiology and Pain Medicine, University of Washington School of Medicine, Seattle, WA, USA.
Javier TrabaLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA; Instituto Universitario de Biología Molecular-UAM (IUBM-UAM), Departamento de Biología Molecular, Universidad Autónoma de Madrid, Madrid, Spain; Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid (CSIC-UAM), Madrid, Spain.
Michael N SackLaboratory of Mitochondrial Biology and Metabolism, NHLBI, NIH, Bethesda, MD, USA; Department of Biochemistry and Cambridge Systems Biology Centre, University of Cambridge, Cambridge, UK. Electronic address: sackm@nih.gov.
National Heart Lung and Blood Institute · USNational Institutes of Health · USUniversity of Cambridge · GBConsejo Superior de Investigaciones Científicas · ESUniversity of Aberdeen · GBUniversity of Washington · US
Funding
Mitochondrial Biology in DiseaseZIAHL005102 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI SACK, MICHAEL · 2009 to 2025
$22.7MFatty acid oxidation suppresses cardiac hypertrophyR01HL129510 · NHLBI · UNIVERSITY OF WASHINGTON · PI TIAN, RONG · 2015 to 2018
$2.8MMultiplexed UPLC-MS/MS System for Advanced Target MetabolomicsS10OD021562 · OD · UNIVERSITY OF WASHINGTON · PI RAFTERY, DANIEL · 2016 to 2016
$596kIntramural NIH HHS ZIA HL005102Medical Research Council MR/P011705/1Medical Research Council MR/P011705/2NHLBI NIH HHS R01 HL129510NIH HHS S10 OD021562
Abstract
To evaluate whether nicotinamide adenine dinucleotide-positive (NAD
Indexed as
AntioxidantsNADHumansInflammationNF-E2-Related Factor 2Oxidation-ReductionSequestosome-1 ProteinAntioxidantsNADNF-E2-Related Factor 2Sequestosome-1 Proteinarginine biosynthesisCD4(+) T cellNAD(+) boostingnicotinamide ribosidenrf2psoriasisTh17 cell
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.