ArticleJournal of experimental botany2023
Old poisons, new signaling molecules: the case of hydrogen cyanide.
Article in Journal of experimental botany, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06491095 (A Randomized, Controlled, Cross-over Trial Examining the Effect of Flaxseed on Blood Cyanide Levels in Healthy Adults), which is not on this map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized, Controlled, Cross-over Trial Examining the Effect of Flaxseed on Blood Cyanide Levels in Healthy Adults
Who cites it
12 citing papers in PubMed, 32 citations in OpenAlex.
- Diverse biosynthetic pathways in Arctic hydrothermal biofilms.Nature communications · 2026Article
- Revealing Functional Traits of Insect Pest Suppressive Rhizobacterial Strains Through Comparative Genomics.Environmental microbiology · 2026Article
- Tunable and self-reporting esterase-activated cyanide prodrugs exert cytoprotective effects.Nature communications · 2026Article
- HPlant, cell & environment · 2026Article
- Metabolic Enzyme MeHNL11 Regulates MeCAS1b Transcription for Cyanide Reutilization in Response to Nitrate Deficiency in Cassava.Plant biotechnology journal · 2026Article
- Review
- Uncovering the poisonous aconitine containing plants in homemade herbal liquor using a convergent approach.Scientific reports · 2025Article
- Gases define redox signalling: NO, HNature metabolism · 2025Article
- Plant Cyanogenic-Derived Metabolites and Herbivore Counter-Defences.Plants (Basel, Switzerland) · 2024Review
- Distinct microbiota assembly and functional patterns in disease-resistant and susceptible varieties of tobacco.Frontiers in microbiology · 2024Article
- New Insights on the Role of ß-Cyanoalanine Synthase CAS-C1 in Root Hair Elongation through Single-Cell Proteomics.Plants (Basel, Switzerland) · 2023Article
- Advances in plant molecular biology: towards new challenges.Journal of experimental botany · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high phenotypic plasticity developed by plants includes rapid responses and adaptations to aggressive or changing environments. To achieve this, they evolved extremely efficient mechanisms of signaling mediated by a wide range of molecules, including small signal molecules. Among them, hydrogen cyanide (HCN) has been largely ignored due to its toxic characteristics. However, not only is it present in living organisms, but it has been shown that it serves several functions in all kingdoms of life. Research using model plants has changed the traditional point of view, and it has been demonstrated that HCN plays a positive role in the plant response to pathogens independently of its toxicity. Indeed, HCN induces a response aimed at protecting the plant from pathogen attack, and the HCN is provided either exogenously (in vitro or by some cyanogenic bacteria species present in the rhizosphere) or endogenously (in reactions involving ethylene, camalexin, or other cyanide-containing compounds). The contribution of different mechanisms to HCN function, including a new post-translational modification of cysteines in proteins, namely S-cyanylation, is discussed here. This work opens up an expanding 'HCN field' of research related to plants and other organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.