Evidence map›Paper›PMID 37584829›Full record

ArticleHuman cell2023

PIAS1 impedes vascular endothelial injury and atherosclerotic plaque formation in diabetes by blocking the RUNX3/TSP-1 axis.

Qingsong Jin, Tiantian Zhao, Liangyan Lin, Xiaoyan Yao, Yaqin Teng, Dongdong Zhang, Yongjun Jin, Meizi Yang

Abstract read
PubMed Publisher
In one paragraph

Article in Human cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. [Risk Nomogram Prediction Model for Cerebral Edema in Patients With Hypertensive Intracerebral Hemorrhage].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qingsong Jin *Department of Endocrinology and Metabolism, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Mouping District, Binzhou, 264100, Shandong Province, People's Republic of China.
Tiantian Zhao *Department of Endocrinology and Metabolism, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Mouping District, Binzhou, 264100, Shandong Province, People's Republic of China.
Liangyan LinDepartment of Endocrinology and Metabolism, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Mouping District, Binzhou, 264100, Shandong Province, People's Republic of China.
Xiaoyan YaoDepartment of Endocrinology and Metabolism, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Mouping District, Binzhou, 264100, Shandong Province, People's Republic of China.
Yaqin TengDepartment of Endocrinology and Metabolism, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Mouping District, Binzhou, 264100, Shandong Province, People's Republic of China.
Dongdong ZhangDepartment of Endocrinology and Metabolism, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Mouping District, Binzhou, 264100, Shandong Province, People's Republic of China.
Yongjun JinDepartment of Endocrinology and Metabolism, Yantai Affiliated Hospital of Binzhou Medical University, No. 717, Mouping District, Binzhou, 264100, Shandong Province, People's Republic of China. endojin@bzmc.edu.cn.
Meizi YangDepartment of Pharmacology, School of Basic Medical Sciences, Binzhou Medical University, No. 522, Huanghe Third Road, Binzhou, 264003, People's Republic of China. meizyang@126.com.
Binzhou Medical University · CNBinzhou University · CN

Funding

National Natural Science Foundation of China No. 81273200
6 · The paper itself

Abstract

The protein PIAS1 functions as a type of ubiquitin-protease, which is known to play an important regulatory role in various diseases, including cardiovascular diseases and cancers. Its mechanism of action primarily revolves around regulating the transcription, translation, and modification of target proteins. This study investigates role and mechanism of PIAS1 in the RUNX3/TSP-1 axis and confirms its therapeutic effects on diabetes-related complications in animal models. A diabetic vascular injury was induced in human umbilical vein endothelial cells (HUVECs) by stimulation with H

Indexed as

Core Binding Factor Alpha 3 SubunitDiabetes Mellitus, ExperimentalEndothelium, VascularPlaque, AtheroscleroticProtein Inhibitors of Activated STATSmall Ubiquitin-Related Modifier ProteinsAnimalsApoptosisCells, CulturedDisease Models, AnimalGlycation End Products, AdvancedHumansHuman Umbilical Vein Endothelial CellsMiceSumoylationCore Binding Factor Alpha 3 SubunitGlycation End Products, AdvancedPIAS1 protein, humanProtein Inhibitors of Activated STATRunx3 protein, humanSmall Ubiquitin-Related Modifier ProteinsAtherosclerotic plaque formationDiabetesPISA1RUNX3SUMOylationTSP-1Vascular endothelial injury

Identifiers

PMID37584829
OpenAlexW4385851609

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.