Evidence map›Paper›PMID 37584772›Full record

ArticleLangenbeck's archives of surgery2023

Prognosis of repeat hepatectomy for liver transplantable hepatocellular carcinoma recurrence after hepatectomy: a Retrospective Cohort Study with the Hiroshima Surgical Study Group of Clinical Oncology (HiSCO).

Masahiro Ohira, Tsuyoshi Kobayashi, Michinori Hamaoka, Tomoyuki Abe, Takashi Onoe, Masashi Inoue, Naruhiko Honmyo, Koichi Oishi, Hideki Ohdan, Hiroshima Surgical study group of Clinical Oncology (HiSCO)

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Article in Langenbeck's archives of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
–field-weighted citation impact, top 76% of its field
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

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0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors at 7 institutions in 1 country.

Masahiro OhiraDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, Japan. mohira@hiroshima-u.ac.jp.
Tsuyoshi KobayashiDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, Japan.
Michinori HamaokaDepartment of Surgery, Hiroshima Prefectural Hospital, Hiroshima, Japan.
Tomoyuki AbeDepartment of Surgery, JA Onomichi General Hospital, Onomichi City, Japan.
Takashi OnoeDepartment of Surgery, National Hospital Organization Kure Medical Center and Chugoku Cancer Center, Kure City, Japan.
Masashi InoueDepartment of Surgery, Higashihiroshima Medical Center, Higashihiroshima City, Japan.
Naruhiko HonmyoDepartment of Surgery, Hiroshima City Asa Citizens Hospital, Hiroshima, Japan.
Koichi OishiDepartment of Surgery, Chugoku Rosai Hospital, Kure City, Japan.
Hideki OhdanDepartment of Gastroenterological and Transplant Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-Ku, Hiroshima, Japan.
Hiroshima Surgical study group of Clinical Oncology (HiSCO)
Hiroshima University · JPChugoku Rosai Hospital · JPHigashihiroshima Medical Center · JPHiroshima City Asa Citizens Hospital · JPHiroshima Prefectural Hospital · JPNational Hospital Organization · JPOnomichi General Hospital · JP

Funding

AMED JP22fk0210108Japan Society for the Promotion of Science JP20K09104
6 · The paper itself

Abstract

purposeFactors affecting the prognosis of repeat hepatectomy for transplantable hepatocellular carcinoma (HCC) recurrence after hepatectomy remain unclear. We aimed to clarify the prognostic factors for transplantable hepatocellular carcinoma recurrence after hepatectomy.

methodsWe included 1758 primary and 486 repeat hepatectomies out of 2244 for HCC performed between 2006 and 2017 using the Hiroshima Study Group for Clinical Oncology and Surgery database. We first compared survival rates of primary and repeat hepatectomy patients. Subsequently, prognostic factors were analyzed in patients who underwent a repeat hepatectomy for transplantable hepatocellular carcinoma recurrence after hepatectomy (defined as age < 70 years at the time of recurrence and recurrent tumor morphology that meets the Milan criteria).

resultsThe 5-year overall survival rate (OS) after repeat hepatectomy was 63.2%, while the 5-year recurrence-free survival rate (RFS) was 23.7%. RFS demonstrated significant inferiority in the repeat hepatectomy group than in the primary hepatectomy group; however, OS did not present a notable difference between the two cohorts. In the transplantable recurrence group, mALBI grade 2b, max tumor size > 20 mm, and multiple tumors were independent prognostic risk factors for overall survival. Patients with two or more risk factors had a significantly lower survival rate (only 30.6% at 5 years) compared to those with one or fewer risk factors (81.8% at 5 years).

conclusionsWe identified the risk factors involved in post-hepatectomy survival for patients with transplantable recurrence after hepatectomy. The results are a potential indicator of whether salvage liver transplantation should be considered during repeat hepatectomy.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsAgedHepatectomyHumansMedical OncologyNeoplasm Recurrence, LocalPrognosisRetrospective StudiesHepatectomyHepatocellular carcinomaLiver transplantationRecurrence

Identifiers

PMID37584772
OpenAlexW4385850767

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.