Evidence map›Paper›PMID 37584614›Full record

ArticleXenobiotica; the fate of foreign compounds in biological systems2023

The influence of temperature on the metabolic activity of CYP2C9, CYP2C19, and CYP3A4 genetic variants

Michiaki Kojima, Kanami Machida, Sumie Cho, Daichi Watanabe, Hiroyuki Seki, Miyuki Shimoji, Ayuko Imaoka, Hiroshi Yamazaki, F Peter Guengerich, Katsunori Nakamura and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Xenobiotica; the fate of foreign compounds in biological systems, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Michiaki KojimaDivision of Clinical Pharmacokinetics, Faculty of Pharmacy, Keio University, Tokyo, Japan.
Kanami MachidaDivision of Clinical Pharmacokinetics, Faculty of Pharmacy, Keio University, Tokyo, Japan.
Sumie ChoDivision of Clinical Pharmacokinetics, Faculty of Pharmacy, Keio University, Tokyo, Japan.
Daichi WatanabeDivision of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Hiroyuki SekiDivision of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan.
Miyuki ShimojiDepartment of Pharmacy, University of the Ryukyus Hospital, Okinawa, Japan.
Ayuko ImaokaDivision of Clinical Pharmacokinetics, Faculty of Pharmacy, Keio University, Tokyo, Japan.
Hiroshi YamazakiLaboratory of Drug Metabolism and Pharmacokinetics, Showa Pharmaceutical University, Tokyo, Machida, Japan.ORCID 0000-0002-1068-4261
F Peter GuengerichDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, USA.
Katsunori NakamuraDepartment of Pharmacy, University of the Ryukyus Hospital, Okinawa, Japan.
Koujirou YamamotoGunma University Graduate School of Medicine, Gunma, Japan.
Takeshi AkiyoshiDivision of Clinical Pharmacokinetics, Faculty of Pharmacy, Keio University, Tokyo, Japan.
Hisakazu OhtaniDivision of Clinical Pharmacokinetics, Faculty of Pharmacy, Keio University, Tokyo, Japan.

Funding

Metabolism of Carcinogens and Drugs by Human P450sR01GM118122 · NIGMS · VANDERBILT UNIVERSITY · PI GUENGERICH, F PETER · 2016 to 2023
$3.3M
NIGMS NIH HHS R01 GM118122
6 · The paper itself

Abstract

1. Temperature is considered to affect the activity of drug-metabolizing enzymes; however, no previous studies have compared temperature dependency among cytochrome P450 genetic variants. This study aimed to analyse warfarin 7-hydroxylation by CYP2C9 variants; omeprazole 5-hydroxylation by CYP2C19 variants; and midazolam 1-hydroxylation by CYP3A4 variants at 34 °C, 37 °C, and 40 °C.2. Compared with that seen at 37 °C, the intrinsic clearance rates (

Indexed as

Aryl Hydrocarbon HydroxylasesCytochrome P-450 CYP3ACytochrome P-450 CYP2C19Cytochrome P-450 CYP2C9HumansTemperatureAryl Hydrocarbon HydroxylasesCYP2C19 protein, humanCYP2C9 protein, humanCYP3A4 protein, humanCytochrome P-450 CYP2C19Cytochrome P-450 CYP2C9Cytochrome P-450 CYP3Abody temperatureCYP alleleCytochrome p450genetic polymorphismhyperthermiahypothermiatemperature sensitivity

Identifiers

PMID37584614
PMCPMC11549676

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.