Evidence map›Paper›PMID 37584553›Full record

ArticleThe Journal of general virology2023

Hypoxia dampens innate immune signalling at early time points and increases Zika virus RNA levels in iPSC-derived macrophages.

Mirjam Schilling, Alun Vaughan-Jackson, William James, Jane A McKeating

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of general virology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Emerging microbes & infections · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mirjam SchillingNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.
Alun Vaughan-JacksonJames & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
William JamesJames & Lillian Martin Centre, Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, UK.
Jane A McKeatingNuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.
University of Oxford · GB

Funding

Medical Research Council MR/R022011/1Wellcome TrustWellcome Trust 200838/Z/16/ZWellcome Trust 203805/Z/16/Z
6 · The paper itself

Abstract

Type I interferons (IFNs) are the major host defence against viral infection and are induced following activation of cell surface or intracellular pattern recognition receptors, including retinoic-acid-inducible gene I (RIG-I)-like receptors (RLRs). All cellular processes are shaped by the microenvironment and one important factor is the local oxygen tension. The majority of published studies on IFN signalling are conducted under laboratory conditions of 18% oxygen (O

Indexed as

Induced Pluripotent Stem CellsInterferon Type IZika VirusZika Virus InfectionDEAD Box Protein 58HumansHypoxiaImmunity, InnateMacrophagesOxygenReceptors, ImmunologicRNADEAD Box Protein 58Interferon Type IOxygenReceptors, ImmunologicRNAHIFhypoxiaIFNiPSCISGsMX1RIG-IZIKV

Identifiers

PMID37584553
PMCPMC10877081
OpenAlexW4385850870

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.