Evidence map›Paper›PMID 37584370›Full record

ArticleBioanalysis2023

An LC-MS/MS method for simultaneous determination of LB-100 and its active metabolite, endothall, in human plasma.

Ye Feng, Erminia Massarelli, Eric Forman, John S Kovach, Ravi Salgia, Timothy W Synold

Open access · greenAbstract read
In one paragraph

Article in Bioanalysis, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ye FengDepartment of Medical Oncology & Therapeutics Research, City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA.
Erminia MassarelliDepartment of Medical Oncology & Therapeutics Research, City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA.
Eric FormanLIXTE Biotechnology, Inc. 680 E Colorado Blvd, Suite 180, Pasadena, CA 91101, USA.
John S KovachLIXTE Biotechnology, Inc. 680 E Colorado Blvd, Suite 180, Pasadena, CA 91101, USA.
Ravi SalgiaDepartment of Medical Oncology & Therapeutics Research, City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA.
Timothy W SynoldDepartment of Medical Oncology & Therapeutics Research, City of Hope, 1500 East Duarte Rd, Duarte, CA 91010, USA.ORCID 0000-0002-4075-2544
City of Hope · USLixte (United States) · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI XIWEI WU · 1985 to 2026
$86.3M
NCI NIH HHS P30 CA033572
6 · The paper itself

Abstract

We have developed and validated a novel LC-MS/MS method for the simultaneous quantification of LB-100 and its active metabolite, endothall, in human plasma following solid-phase extraction. LB-105 and endothall-D6 were used as internal standards. Chromatographic separation was achieved on a Hypercarb™ column using 5 mM (NH

Indexed as

Tandem Mass SpectrometryChromatography, High Pressure LiquidChromatography, LiquidDicarboxylic AcidsHumansPiperazinesReference StandardsReproducibility of ResultsDicarboxylic AcidsendothallLB100Piperazineschromatographyendothallhuman plasmaLB-100LC–MSmass spectrometryoncologypharmacokineticsvalidation

Identifiers

PMID37584370
PMCPMC10505989
OpenAlexW4385851615

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.