Evidence map›Paper›PMID 37584273›Full record

ArticleThe Journal of infectious diseases2024

Changes in Inflammatory Cytokine Levels in Rectal Mucosa Associated With Neisseria gonorrheae and/or Chlamydia trachomatis Infection and Treatment Among Men Who Have Sex With Men in Lima, Peru.

Jesse L Clark, Catherine E Oldenburg, Ryan C Passaro, Eddy R Segura, William Godwin, Jennifer A Fulcher, Robinson Cabello

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of infectious diseases, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03010020 (STI Screening as a Combined HIV Prevention Platform for MSM in Peru), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03010020 nacompletednot on this map

STI Screening as a Combined HIV Prevention Platform for MSM in Peru

TypeinterventionalSponsorUniversity of California, Los AngelesRan2017 to 2018Enrolled150ConditionsGonorrhoea of Rectum, Chlamydia of Rectum, HIV InfectionsArmsPCC, Traditional Counseling
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 2 countries.

Jesse L ClarkDavid Geffen School of Medicine, Department of Medicine, Division of Infectious Diseases, University of California, Los Angeles, Los Angeles, California, USA.ORCID 0000-0001-5862-6530
Catherine E OldenburgProctor Foundation for Research in Ophthalmology, University of California, San Francisco, San Francisco, California, USA.
Ryan C PassaroDepartment of Emergency Medicine, University of Southern California, Los Angeles County Hospital, Los Angeles, California, USA.
Eddy R SeguraFacultad de Ciencias de la Salud, Universidad Peruana de Ciencias Aplicadas, Lima, Peru.
William GodwinSan Francisco Department of Public Health, San Francisco, California, USA.
Jennifer A FulcherDavid Geffen School of Medicine, Department of Medicine, Division of Infectious Diseases, University of California, Los Angeles, Los Angeles, California, USA.
Robinson CabelloAsociacion Civil Via Libre, Lima, Peru.
University of California, Los Angeles · USAsociación Civil Impacta Salud y Educación · PEPeruvian University of Applied Sciences · PESan Francisco Department of Public Health · USUniversity of California, San Francisco · USUniversity of Southern California · US

Funding

STI Screening as a Combined HIV Prevention Platform for MSM in PeruR34MH105272 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CLARK, JESSE LAWTON · 2015 to 2017
$604k
NIH HHS R34 MH105272NIMH NIH HHS R34 MH105272
6 · The paper itself

Abstract

backgroundNeisseria gonorrheae and Chlamydia trachomatis are associated with mucosal inflammation and human immunodeficiency virus 1 (HIV-1) transmission. We assessed levels of inflammatory cytokines in men who have sex with men (MSM) with and without rectal gonorrhea and/or chlamydia in Lima, Peru.

methodsWe screened 605 MSM reporting condomless receptive anal intercourse for rectal N. gonorrheae/C. trachomatis using nucleic acid testing. We identified 101 cases of gonorrhea and/or chlamydia and randomly selected 50 N. gonorrheae/C. trachomatis positive cases and matched 52 negative controls. We measured levels of IL-1β, IL-6, IL-8, and TNF-α in rectal secretions. Tests for HIV-1, rectal N. gonorrheae/C. trachomatis, and mucosal cytokines were repeated after 3 and 6 months. Cytokine levels in cases and uninfected controls were compared using Wilcoxon rank-sum tests and linear regression.

resultsMSM with gonorrhea/chlamydia had elevated levels of all cytokines in rectal mucosa compared with matched controls (all P values <.001). Following antibiotic treatment there were no significant differences in cytokine levels at 3- or 6-month follow-up evaluations (all P values >.05). DISCUSSION: Rectal gonorrhea/chlamydia infection is associated with transient mucosal inflammation and cytokine recruitment. Our data provide proof of concept for rectal sexually transmitted infection screening as an HIV prevention strategy for MSM. Clinical Trials Registration. NCT03010020.

Indexed as

Chlamydia InfectionsGonorrheaHIV-1HIV InfectionsRectal DiseasesSexual and Gender MinoritiesChlamydia trachomatisCytokinesHomosexuality, MaleHumansInflammationMaleMucous MembraneNeisseria gonorrhoeaePeruPrevalenceCytokineschlamydiaChlamydia trachomatiscytokinesgonorrheaHIV-1HIV-1 preventioninflammationMSMNeisseria gonorrheaerectal mucosa

Identifiers

PMID37584273
PMCPMC10938210
OpenAlexW4385850447

What OpenQuestion holds

Textmetadata
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.