Evidence map›Paper›PMID 37584258›Full record

ArticleThoracic cancer2023

Breviscapine reverses doxorubicin resistance in breast cancer and its related mechanisms.

Weijiang Fu, Jie Song, Haiying Li

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Thoracic cancer, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06195371 (The Impact of CASP3 Gene in Chemoresistant Breast Cancer), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.7field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06195371 not yet recruitingnot on this mapstarted 2024, after this paper: background citation

The Impact of CASP3 Gene in Chemoresistant Breast Cancer

TypeobservationalSponsorGehad Salah El-Din shakerRan2024 to 2026Enrolled60ConditionsBreast Cancer
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Weijiang FuDepartment of Geriatric Medicine & Shandong Key Laboratory Cardiovascular Proteomics, Qilu Hospital of Shandong University, Jinan, China.
Jie SongDepartment of Medical Insurance, Qilu Hospital of Shandong University, Jinan, China.
Haiying LiDepartment of Ultrasound, Qilu Hospital of Shandong University, Jinan, China.ORCID 0000-0001-5847-0687
Qilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBased on the effect of breviscapine (BRE) on reversing drug resistance of human breast cancer cell line MCF-7/doxorubicin (Dox), the mechanism was preliminarily explored.

methodsThe methyl thiazolyl tetrazolium (MTT) method was introduced to detect inhibitory effect of Dox alone or in combination with BRE on MCF-7 (M) and MCF-7/Dox (MD) cells, and the inhibitory concentration (IC

resultsThe IC

conclusionBRE could increase the MD sensitivity to Dox via increasing Bax and cleaved-caspase-3 expression and inhibiting Bcl-2 expression, thereby promoting cell apoptosis. BRE reversed Dox resistance of MD cells by increasing Dox intracellular accumulation through inhibiting P-gp expression via EGFR.

Indexed as

Breast NeoplasmsAntibiotics, AntineoplasticApoptosisATP Binding Cassette Transporter, Subfamily B, Member 1bcl-2-Associated X ProteinCaspase 3Cell Line, TumorDoxorubicinDrug Resistance, MultipleDrug Resistance, NeoplasmErbB ReceptorsFemaleFlavonoidsHumansAntibiotics, AntineoplasticATP Binding Cassette Transporter, Subfamily B, Member 1bcl-2-Associated X ProteinbreviscapineCaspase 3DoxorubicinErbB ReceptorsFlavonoidsapoptosisbreast cancerbreviscapinedoxorubicinP-gp

Identifiers

PMID37584258
PMCPMC10518232
OpenAlexW4385851412

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.