ReviewDeutsches Arzteblatt international2023
Mediation Analysis in Medical Research.
Review in Deutsches Arzteblatt international, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
49 citing papers in PubMed.
- Itch, Scratching, and Sleep Mediate the Association between Disease Severity and Quality of Life in Pruritic Dermatoses: A Cross-Sectional Study.Dermatology and therapy · 2026Article
- Apolipoprotein B100 and white matter hyperintensity as distinct mediators of thrombolytic response in acute stroke: preliminary findings.Journal of thrombosis and thrombolysis · 2026Article
- Association of socioeconomic status and lifestyle factors with incident diabetes among individuals with prediabetes: a prospective cohort study from UK Biobank.Preventive medicine reports · 2026Article
- Educational Inequalities and Obesity: Association and Attenuation After Lifestyle Adjustment in a Cross-Sectional Working-Age Population.Medical sciences (Basel, Switzerland) · 2026Article
- Mendelian randomization study on the effects of women's reproductive traits and socioeconomic traits on pregnancy complications.BMC pregnancy and childbirth · 2026Article
- Association between serum methylmalonic acid and metabolic dysfunction-associated steatotic liver disease: NHANES-based study.Medicine · 2026Article
- Associations and Pathways Between Online Health Information-Seeking Behavior and Patient Adherence: Cross-Sectional Study.Journal of medical Internet research · 2026Article
- Interaction and Joint Effects of Inflammation and Triglyceride-Glucose (TyG) Index on Hyperuricemia Risk and the Mediating Role of TyG: A Cross-Sectional Study.Endocrinology, diabetes & metabolism · 2026Article
- Genetically predicted inflammatory cytokines mediate the associations between the gut microbiota and ovarian cancer: a bidirectional two-sample Mendelian randomization study.Journal of ovarian research · 2026Article
- The Effects of Gut Microbiota, Plasma Metabolites, Immune Cells, Blood Cells and Cytokines on Schizophrenia: A Bidirectional Two-Sample Mendelian Randomisation Study.Actas espanolas de psiquiatria · 2026Article
- The role of hepatocyte growth factor in the relationship between body fat distribution and plasma markers of glucose metabolism: a cross-sectional study.Diabetology & metabolic syndrome · 2026Article
- The causal interplay between depression and alcohol use from adolescence to young adulthood: a Mendelian randomization study.Psychological medicine · 2026Article
- Association between dehydration trajectory, delayed cerebral ischemia, and functional outcome in patients with aneurysmal subarachnoid hemorrhage: assessment of interaction and mediation.Journal of neurointerventional surgery · 2026Article
- Associations Between Metabolic Syndrome Index, Systemic Inflammatory Index, and Arthritis Subtype in the U.S. and Chinese Adults: A Mediation Analysis.Mediators of inflammation · 2026Article
- eHealth literacy, health self-efficacy, and health-promoting lifestyle among vocational college students: a latent profile and mediation analysis study.Frontiers in public health · 2026Article
- Early-pregnancy ALT, AST, and GGT in relation to gestational diabetes: a GGT-focused association pattern.Frontiers in endocrinology · 2026Article
- Associations between thyroid axis changes and glycemic improvement after weight loss in type 2 diabetes: a mediation analysis.American journal of translational research · 2026Article
- Association between PMFrontiers in public health · 2026Article
- Pericoronary Fat Attenuation Index Mediates the Link Between TyG Index and OSA Risk in Type 2 Diabetes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Controlled Attenuation Parameter and Gallstone Disease Risk: A Retrospective Cohort Study with Mediation Analysis and Longitudinal Trajectory Modeling, Emphasizing Gender-Specific Effects.Clinical epidemiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMediation analysis addresses the question of the mechanisms by which an exposure causes an outcome. This article is intended to convey basic knowledge of statistical mediation analysis.
methodsSelected articles and examples are used to explain the principle of mediation analysis.
resultsThe goal of mediation analysis is to express an overall exposure effect as a combination of an indirect and a direct effect. For example, it might be of interest whether the increased risk of diabetes (outcome) due to obesity (exposure) is mediated by insulin resistance (indirect effect), and, if so, how much of a direct effect remains. In this example, insulin resistance is a potential mediator of the effect of obesity on the risk of diabetes. In general, for a mediation analysis to be valid, more confounders must be taken into account than in the estimation of the overall effect size. A regression-based approach can be used to ensure the consideration of all relevant confounders in a mediation analysis.
conclusionBy decomposing the overall exposure effect into indirect and direct components, a mediation analysis can reveal not just whether an exposure causes an outcome, but also how. For a mediation analysis to be valid, however, multiple assumptions must be satisfied that cannot easily be checked, potentially compromising such analyses as compared to the estimation of an overall effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.