Evidence map›Paper›PMID 37584094›Full record

Trial reportActa dermato-venereologica2023

Prolonged Antipruritic Effect of Botulinum Toxin Type A on Cowhage-induced Itch: A Randomized, Single-blind, Placebo-controlled Trial.

Leigh A Nattkemper, Ashley Vander Does, Carolyn M Stull, Michael J Lavery, Rodrigo Valdes-Rodriguez, Marlene McGregory, Yiong Huak Chan, Gil Yosipovitch

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta dermato-venereologica, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Leigh A NattkemperDepartment of Dermatology, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Ashley Vander DoesDepartment of Dermatology, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Carolyn M StullDepartment of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Michael J LaveryDepartment of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Rodrigo Valdes-RodriguezDepartment of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Marlene McGregoryDepartment of Dermatology, Temple University Lewis Katz School of Medicine, Philadelphia, PA, USA.
Yiong Huak ChanBiostatistics Unit, National University of Singapore Lon Lin School of Medicine, Singapore, Singapore.
Gil YosipovitchDepartment of Dermatology, Miami Itch Center, University of Miami Miller School of Medicine, Miami, FL, USA. gyosipovitch@med.miami.edu.
Temple University · USUniversity of Miami · USNational University of Singapore · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Botulinum toxin type A (Botox) is thought to have antipruritic effects through inhibition of pruritic factors, including acetylcholine, substance P, and glutamate. The aim of this randomized, single-blind, placebo-controlled trial was to test the effect of botulinum toxin type A on cowhage, a non-histaminergic model for chronic itch. Botulinum toxin type A was injected into the arm of 35 healthy subjects, with a saline control injected into the contralateral arm. Thermal sensory parameters (warmth and heat thresholds and heat pain intensity) and itch intensity after cowhage application were examined on test areas. Botulinum toxin type A reduced itch intensity, overall perceived itch (area under the curve (AUC); percentage change from baseline), and peak itch intensity compared with the control at 1 week, 1 month, and 3 months. Botulinum toxin type A had no effect on thermal thresholds or heat pain intensity. In conclusion, botulinum toxin type A reduced cowhage itch for at least 3 months, which suggests that botulinum toxin type A is a potential long-lasting treatment for localized, non-histaminergic itch.

Indexed as

Botulinum Toxins, Type AAntipruriticsDouble-Blind MethodHumansPain MeasurementPruritusSingle-Blind MethodAntipruriticsBotulinum Toxins, Type A

Identifiers

PMID37584094
PMCPMC10442928
OpenAlexW4385851659

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.