ArticleInternational journal of clinical and health psychology : IJCHP
Childhood trauma is linked to abnormal static-dynamic brain topology in adolescents with major depressive disorder.
Article in International journal of clinical and health psychology : IJCHP. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Optimal intensity and dose of exercise to improve university students' mental health: a systematic review and network meta-analysis of 48 randomized controlled trials.European journal of applied physiology · 2025Pooled it
- Graph theory reveals functional connectome disruptions in adolescent major depressive disorder with childhood trauma.Communications medicine · 2026Article
- Associations of childhood trauma with clinical features and inflammatory cytokines in adolescents with first-episode and recurrent major depressive disorder.Frontiers in immunology · 2026Article
- White matter functional connectome topology and its clinical correlations in adolescent major depressive disorder.Psychoradiology · 2026Article
- Association between usage intensity of short video platforms and altered brain function: a resting-state functional magnetic resonance imaging study.Frontiers in human neuroscience · 2026Article
- Default mode network static-dynamic functional signatures in first-episode drug-naive major depressive disorder.Comprehensive psychoneuroendocrinology · 2025Article
- Aberrant Flexibility of Dynamic Brain Network in Patients with Autism Spectrum Disorder.Bioengineering (Basel, Switzerland) · 2024Article
- Self-concept mediates the relationships between childhood traumatic experiences and adolescent depression in both clinical and community samples.BMC psychiatry · 2024Article
- Sex differences in human brain networks in normal and psychiatric populations from the perspective of small-world properties.Frontiers in psychiatry · 2024Review
- Effects of aerobic exercise on cognitive function in adults with major depressive disorder: A systematic review and meta-analysis.International journal of clinical and health psychology : IJCHPArticle
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Authors and funding
14 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Childhood trauma is a leading risk factor for adolescents developing major depressive disorder (MDD); however, the underlying neuroimaging mechanisms remain unclear. This study aimed to investigate the association among childhood trauma, MDD and brain dysfunctions by combining static and dynamic brain network models. We recruited 46 first-episode drug-naïve adolescent MDD patients with childhood trauma (MDD-CT), 53 MDD patients without childhood trauma (MDD-nCT), and 90 healthy controls (HCs) for resting-state functional magnetic resonance imaging (fMRI) scans; all participants were aged 13-18 years. Compared to the HCs and MDD-nCT groups, the MDD-CT group exhibited significantly higher global and local efficiency in static brain networks and significantly higher temporal correlation coefficients in dynamic brain network models at the whole-brain level, and altered the local efficiency of default mode network (DMN) and temporal correlation coefficients of DMN, salience (SAN), and attention (ATN) networks at the local perspective. Correlation analysis indicated that altered brain network features and clinical symptoms, childhood trauma, and particularly emotional neglect were highly correlated in adolescents with MDD. This study may provide new evidence for the dysconnectivity hypothesis regarding the associations between childhood trauma and MDD in adolescents from the perspectives of both static and dynamic brain topology.
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