Evidence map›Paper›PMID 37583856›Full record

ArticleWorld journal of clinical cases2023

Acute myelomonocytic leukemia and T-lymphoblastic lymphoma as simultaneous bilineage hematologic malignancy treated with decitabine: A case report.

So-Yeon Jeon, Na-Ri Lee, Seungah Cha, Ho-Young Yhim, Jae-Yong Kwak, Kyu Yun Jang, Namsu Kim, Yong Gon Cho, Chang-Hoon Lee

Open access · diamondAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of clinical cases, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

So-Yeon JeonDepartment of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea.
Na-Ri LeeDepartment of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea.
Seungah ChaDepartment of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea.
Ho-Young YhimDepartment of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea.
Jae-Yong KwakDepartment of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea.
Kyu Yun JangDepartment of Pathology, Jeonbuk National University Medical School, Jeonju 54907, South Korea.
Namsu KimDepartment of Laboratory Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea.
Yong Gon ChoDepartment of Laboratory Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea.
Chang-Hoon LeeDepartment of Internal Medicine, Jeonbuk National University Medical School, Jeonju 54907, South Korea. rednose2000@hanmail.net.
Jeonbuk National University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSimultaneous bilineage hematologic malignancies are rare; however, several cases of acute myeloid leukemia (AML) and T-lymphoblastic lymphoma (T-LBL) co-occurrence have been reported. A standard treatment for simultaneous AML and T-LBL has not yet been established, and its prognosis is very poor. Further studies to develop standard treatments are required to increase patient survival rates. CASE SUMMARY: A 69-year-old man complaining of pleuritic chest pain visited the emergency room. Computed tomography revealed multiple enlarged lymph nodes (LNs) in the neck and groin and pulmonary thromboembolism with pulmonary infarction. Furthermore, a peripheral blood smear performed due to leukocytosis revealed circulating blasts. Acute myelomonocytic leukemia (AMML) was diagnosed after bone marrow examination, and T-LBL positivity for terminal deoxynucleotidyl transferase, cluster of differentiation (CD)34, and CD4 was confirmed by cervical LN biopsy. Decitabine and dexamethasone were administered because he could not receive intensive chemotherapy due to poor performance status. Complete remission of AMML and T-LBL was achieved after 4 cycles of decitabine plus dexamethasone.

conclusionWe report the therapeutic effect of decitabine, a hypomethylating agent (HMA), in patients with concurrent bilineage hematologic malignancies and suggest that further studies are required to evaluate the therapeutic effect of HMAs on both lymphoid and bilineage hematologic malignancies.

Indexed as

Acute myelomonocytic leukemiaCase reportDecitabinePulmonary thromboembolismSimultaneous bilineage hematologic malignanciesT-lymphoblastic lymphoma

Identifiers

PMID37583856
PMCPMC10424015
OpenAlexW4385247924

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.