Evidence map›Paper›PMID 37583810›Full record

ArticleACS medicinal chemistry letters2023

Hydroxyethyl-Modified Cycloheptatriene-BODIPY Derivatives as Specific Tau Imaging Probes.

Yuying Li, Chuan Tian, Tianxin Xie, Qi-Lei Zhang, Jiaqi Liu, Xiao-Xin Yan, Jiapei Dai, Yi Liang, Mengchao Cui

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS medicinal chemistry letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 7 citations in OpenAlex.

  1. Alzheimer's disease pathophysiology in the Retina.Progress in retinal and eye research · 2024
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Yuying LiKey Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing 100875, China.
Chuan TianKey Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing 100875, China.
Tianxin XieKey Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing 100875, China.
Qi-Lei ZhangDepartment of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, China.
Jiaqi LiuCollege of Life Sciences, Taikang Center for Life and Medical Science, Hubei Key Laboratory of Cell Homeostasis, Wuhan University, Wuhan 430072, China.
Xiao-Xin YanDepartment of Anatomy and Neurobiology, Xiangya School of Medicine, Central South University, Changsha 410013, China.
Jiapei DaiWuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan 430074, China.
Yi LiangCollege of Life Sciences, Taikang Center for Life and Medical Science, Hubei Key Laboratory of Cell Homeostasis, Wuhan University, Wuhan 430072, China.
Mengchao CuiKey Laboratory of Radiopharmaceuticals, Ministry of Education, Beijing Normal University, Beijing 100875, China.ORCID https://orcid.org/0000-0002-3488-7864
Beijing Normal University · CNCentral South University · CNWuhan University · CNSouth Central Minzu University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Near-infrared fluorescence (NIRF) imaging as an exquisite sensitive, high spatial-resolution, and real-time tool plays an important role in visualizing pathologies in the brain. In this study, we designed and synthesized a series of NIR probes of hydroxyethyl cycloheptatriene-BODIPY derivatives that have demonstrated strong binding specificity to native neurofibrillary tangles (NFTs) in Alzheimer's disease (AD) brain sections. The improved hydrophilicity of

Identifiers

PMID37583810
PMCPMC10424304
OpenAlexW4383876281

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.