Evidence map›Paper›PMID 37583550›Full record

ArticleiScience2023

KS-CMI: A circRNA-miRNA interaction prediction method based on the signed graph neural network and denoising autoencoder.

Xin-Fei Wang, Chang-Qing Yu, Zhu-Hong You, Yan Qiao, Zheng-Wei Li, Wen-Zhun Huang, Ji-Ren Zhou, Hai-Yan Jin

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In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

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3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xin-Fei WangSchool of Information Engineering, Xijing University, Xi'an, China.
Chang-Qing YuSchool of Information Engineering, Xijing University, Xi'an, China.
Zhu-Hong YouSchool of Computer Science, Northwestern Polytechnical University, Xi'an, China.
Yan QiaoCollege of Agriculture and Forestry, Longdong University, Qingyang, China.
Zheng-Wei LiSchool of Computer Science and Technology, China University of Mining and Technology, Xuzhou, China.
Wen-Zhun HuangSchool of Information Engineering, Xijing University, Xi'an, China.
Ji-Ren ZhouSchool of Computer Science, Northwestern Polytechnical University, Xi'an, China.
Hai-Yan JinSchool of Computer Science and Engineering, Xi'an University of Technology, Xi'an, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Circular RNA (circRNA) plays an important role in the diagnosis, treatment, and prognosis of human diseases. The discovery of potential circRNA-miRNA interactions (CMI) is of guiding significance for subsequent biological experiments. Limited by the small amount of experimentally supported data and high randomness, existing models are difficult to accomplish the CMI prediction task based on real cases. In this paper, we propose KS-CMI, a novel method for effectively accomplishing CMI prediction in real cases. KS-CMI enriches the 'behavior relationships' of molecules by constructing circRNA-miRNA-cancer (CMCI) networks and extracts the behavior relationship attribute of molecules based on balance theory. Next, the denoising autoencoder (DAE) is used to enhance the feature representation of molecules. Finally, the CatBoost classifier was used for prediction. KS-CMI achieved the most reliable prediction results in real cases and achieved competitive performance in all datasets in the CMI prediction.

Indexed as

Gene networkNeural networks

Identifiers

PMID37583550
PMCPMC10424127

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.