ArticleFrontiers in neuroscience2023
Whole-brain structure-function coupling abnormalities in mild cognitive impairment: a study combining amplitude of low-frequency fluctuations and voxel-based morphometry.
Article in Frontiers in neuroscience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 11 citations in OpenAlex.
- A false discovery rate control method using a fully connected hidden Markov random field for neuroimaging data.Medical image analysis · 2026Article
- Impaired regional structure-function coupling as novel neurophenotype: mechanistic insights and diagnostic exploration in treatment-resistant depression.Npj mental health research · 2026Article
- The nature and interpretation of BOLD signals in white matter - A review.Magnetic resonance imaging · 2026Review
- Functional-Structural Coupling: Brain Reorganization in Presbycusis Is Related to Cognitive Impairment.eNeuro · 2026Article
- Disrupted Brain Structure-Function Coupling and Its Mediating Effects on the Associations Between Cerebral Small Vessel Disease Burden and Cognitive Dysfunction.CNS neuroscience & therapeutics · 2025Article
- Changes of network controllability and structural-function coupling in cerebral small vessel disease.Brain structure & function · 2025Article
- Concurrent brain structural and functional alterations related to cognition in patients with cerebral small vessel disease.Neuroradiology · 2025Article
- Multiparameter resting-state functional magnetic resonance imaging as an indicator of neuropsychological changes in Binswanger's disease with mild cognitive impairment.Frontiers in aging neuroscience · 2025Article
- Altered functional-structural coupling may predict Parkinson's patient's depression.Brain structure & function · 2024Article
- Differences in cerebral structure among patients with amnestic mild cognitive impairment and patients with Alzheimer's disease.Frontiers in aging neuroscience · 2024Article
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Alzheimer's disease (AD), one of the leading diseases of the nervous system, is accompanied by symptoms such as loss of memory, thinking and language skills. Both mild cognitive impairment (MCI) and very mild cognitive impairment (VMCI) are the transitional pathological stages between normal aging and AD. While the changes in whole-brain structural and functional information have been extensively investigated in AD, The impaired structure-function coupling remains unknown. The current study employed the OASIS-3 dataset, which includes 53 MCI, 90 VMCI, and 100 Age-, gender-, and education-matched normal controls (NC). Several structural and functional parameters, such as the amplitude of low-frequency fluctuations (ALFF), voxel-based morphometry (VBM), and The ALFF/VBM ratio, were used To estimate The whole-brain neuroimaging changes In MCI, VMCI, and NC. As disease symptoms became more severe, these regions, distributed in the frontal-inf-orb, putamen, and paracentral lobule in the white matter (WM), exhibited progressively increasing ALFF (ALFF
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