ArticleCanadian journal of psychiatry. Revue canadienne de psychiatrie2024
A History of Suicide Attempt Is Associated with Increased Sympathetic Activation in Bipolar Disorder.
Article in Canadian journal of psychiatry. Revue canadienne de psychiatrie, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Conceptualization From the Sensors to Suicide-Related Outcomes: Scoping Review Based on Layered Hierarchical Sensemaking Framework.JMIR mHealth and uHealth · 2026Article
- Trajectories of Suicidal Risk Impact Mood Regulation Differently in Patients With a Diagnosis of Bipolar Disorder.Acta psychiatrica Scandinavica · 2026Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveSuicide risk in bipolar disorder (BD) is estimated to be up to 20 times higher than in the general population. While there is a large body of evidence suggesting that increased sympathetic activation is associated with disease and death, there is a paucity of research on the role of autonomic nervous system (ANS) dysfunction in patients with BD who have attempted suicide.
methodsFifty-three participants with BD used a wearable device to assess the association between history of suicide attempt, current suicidal ideation, and ANS dysfunction, including measures of heart rate variability (HRV) and respiratory rate. Data were analyzed in a series of unadjusted and adjusted bivariate models of association controlling for relevant variables.
resultsA history of suicide attempts was significantly associated with an increase in respiratory rate (
conclusionsOur results suggest that changes in the ANS in patients with BD and a history of suicide attempt are not restricted to pure vagally mediated HRV parameters, but rather signal a general ANS dysregulation. This ANS imbalance may be contributing to illness burden and cardiovascular disease. Further research on the relationship between ANS and suicidality in BD is needed.
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