ReviewTranslational psychiatry2023
Closing the loop between brain and electrical stimulation: towards precision neuromodulation treatments.
Review in Translational psychiatry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Research trends and knowledge mapping of transcranial direct current stimulation in depression: a bibliometric study based on web of science, Scopus, and PubMed (2000-2025).Frontiers in psychiatry · 2026Pooled it
- Targeting cortico-striatal-amygdalar networks via theta-band frontoparietal synchronization in opioid use disorder: a randomized tACS-fMRI Trial.Molecular psychiatry · 2026Trial
- Trial
- A patient-specific, 3D printed neurostimulator enabling focal transcranial electrical stimulation and EEG at home.Journal of neuroengineering and rehabilitation · 2025Trial
- Alleviating cognitive impairments in bipolar disorder with a novel DTI-guided multimodal neurostimulation protocol: a double-blind randomized controlled trial.BMC medicine · 2025Trial
- Prefrontal Transcranial Direct Current Stimulation in Pediatric Attention-Deficit/Hyperactivity Disorder: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Practice improves older adults' attentional control and prospective memory more than HD-tDCS: a randomized controlled trial.Scientific reports · 2024Trial
- Dose-response in modulating brain function with transcranial direct current stimulation: From local to network levels.PLoS computational biology · 2023Trial
- Electroencephalography research in neuropathic pain (Review).Molecular medicine reports · 2026Review
- Neuromodulation for restoring and amplifying brain function.Nature neuroscience · 2026Review
- Closed-Loop Neuromodulation for Brain Fatigue: From Real-Time Biomarkers to Adaptive Intervention.International journal of molecular sciences · 2026Review
- Rhythmic stimulation elicits multiple, concurrent neural responses.Cerebral cortex (New York, N.Y. : 1991) · 2026Article
- Implant-Grade Neural Sensing with Artifact-Resilient Computational Intelligence Preserves Spatial Fidelity of HFO Biomarkers in Epilepsy.Research square · 2026Article
- Effects of Social Media Use on Brain Dynamics in Young Male Adults: Multistage Concurrent Electroencephalography-Functional Magnetic Resonance Imaging Study.JMIR medical informatics · 2026Article
- I Can't Hear You Both at the Same Time: A Temporal Dilemma During Inter-Regional Communication.eNeuro · 2026Article
- Synaptic Plasticity-Intrinsic Excitability and Antidepressant Discovery.Biomedicines · 2026Review
- Tinnitus.Nature reviews. Disease primers · 2026Review
- Closed-crown packaging system for stable, long-term neural recording in group-housed mice.Microsystems & nanoengineering · 2026Article
- Scalable biomarkers of Parkinson's disease: insights from mobile EEG in Peru.Scientific reports · 2026Article
- Effects of noninvasive brain stimulation on motor functions in animal models of ischemia and trauma in the central nervous system.Neural regeneration research · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors.
Funding
Abstract
One of the most critical challenges in using noninvasive brain stimulation (NIBS) techniques for the treatment of psychiatric and neurologic disorders is inter- and intra-individual variability in response to NIBS. Response variations in previous findings suggest that the one-size-fits-all approach does not seem the most appropriate option for enhancing stimulation outcomes. While there is a growing body of evidence for the feasibility and effectiveness of individualized NIBS approaches, the optimal way to achieve this is yet to be determined. Transcranial electrical stimulation (tES) is one of the NIBS techniques showing promising results in modulating treatment outcomes in several psychiatric and neurologic disorders, but it faces the same challenge for individual optimization. With new computational and methodological advances, tES can be integrated with real-time functional magnetic resonance imaging (rtfMRI) to establish closed-loop tES-fMRI for individually optimized neuromodulation. Closed-loop tES-fMRI systems aim to optimize stimulation parameters based on minimizing differences between the model of the current brain state and the desired value to maximize the expected clinical outcome. The methodological space to optimize closed-loop tES fMRI for clinical applications includes (1) stimulation vs. data acquisition timing, (2) fMRI context (task-based or resting-state), (3) inherent brain oscillations, (4) dose-response function, (5) brain target trait and state and (6) optimization algorithm. Closed-loop tES-fMRI technology has several advantages over non-individualized or open-loop systems to reshape the future of neuromodulation with objective optimization in a clinically relevant context such as drug cue reactivity for substance use disorder considering both inter and intra-individual variations. Using multi-level brain and behavior measures as input and desired outcomes to individualize stimulation parameters provides a framework for designing personalized tES protocols in precision psychiatry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.