Evidence map›Paper›PMID 37582875›Full record

ArticleDoklady. Biochemistry and biophysics2023

The Expression Pattern and Clinical Significance of Lysyl Oxidase Family in Gliomas.

Weijie Xie, Zhongte Peng, Xiao Zhou, Qiaoxi Xia, Mantong Chen, Xiaoqi Zheng, Hong Sun, Haiying Zou, Liyan Xu, Zepeng Du and 2 more

Abstract read
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In one paragraph

Article in Doklady. Biochemistry and biophysics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 33 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Weijie XieDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.
Zhongte PengDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.
Xiao ZhouDepartment of Central Laboratory, Shantou Central Hospital, 515041, Shantou, China.
Qiaoxi XiaDepartment of Central Laboratory, Shantou Central Hospital, 515041, Shantou, China.
Mantong ChenDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.
Xiaoqi ZhengDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.
Hong SunDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.
Haiying ZouDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China.
Liyan XuInstitute of Oncologic Pathology, Shantou University Medical College, 515041, Shantou, China.
Zepeng DuDepartment of Central Laboratory, Shantou Central Hospital, 515041, Shantou, China.
Enmin LiDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China. nmli@stu.edu.cn.
Bingli WuDepartment of Biochemistry and Molecular Biology, Shantou University Medical College, 515041, Shantou, China. blwu@stu.edu.cn.
Shantou University Medical College · CNShantou Central Hospital · CNShantou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

LOX (Lysyl oxidase) family participates in the catalysis of collagen and elastin to maintain ECM homeostasis. Glioma is the most common primary brain tumor and LOX family has not been systemic studied in glioma. In this study, we found LOX family members are upregulated expressed in gliomas samples. A protein-protein interaction network (PPIN) was construct to visualize and understand the differential expression pattern, as well as functional annotation, for LOX family and their interacting proteins, which involved in collagen fibril organization and MAPK signaling pathway. Through subcellular localization distribution, the LOX family members distribute both intracellular and extracellular. All five LOX members are consistently significantly correlate with dendritic cell both in immune infiltrate of GBM and LGG. Survival analysis showed that high expression of LOX family is associated with a poor prognosis of gliomas patients. These analyses provide important clues to identify the potential biological roles for LOX family in gliomas, which might serve as diagnosis markers.

Indexed as

GliomaProtein-Lysine 6-OxidaseClinical RelevanceCollagenHumansCollagenProtein-Lysine 6-Oxidaseexpression patternfunctional enrichmentgliomasLysyl oxidaseprotein-protein interaction network

Identifiers

PMID37582875
OpenAlexW4385831795

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.