ArticleBMC endocrine disorders2023
Threshold effect and sex characteristics of the relationship between chronic inflammation and BMI.
Article in BMC endocrine disorders, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 21 citations in OpenAlex.
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- Sex-, Age-, Lifestyle-, and Comorbidity-Specific Reference Values for Serum Cytokines in the Dutch General Population: Results From the PROFILES Registry.Cancer medicine · 2026Article
- Exploring the relationship between BMI and cognitive function in older adults: The mediating role of recreational physical activity.Medicine · 2026Article
- Sex-biased plasma inflammatory protein profile in obesity.Scientific reports · 2026Article
- Recent Choline Intake Is Inversely Associated with Inflammation in Pregnancy - Evidence from the Canadian APrON Cohort.The Journal of nutrition · 2026Article
- Peripheral inflammation mediates the relationship between early life stress and alcohol use.Psychopharmacology · 2026Article
- Graft remodelling of hamstring ACL graft and secondary meniscal lesions are affected by tibial slope and body mass index.Journal of experimental orthopaedics · 2025Article
- Underpinnings of heart failure with preserved ejection fraction in women - From prevention to improving function. A co-publication with the American Journal of Preventive Cardiology and the Journal of Cardiac Failure.American journal of preventive cardiology · 2025Article
- Gender-Specific Moderating Role of Physical Fitness and Cardiovascular Risk Factors in the Relationship Between BMI and C-Reactive Protein: Cross-Sectional Study.JMIR public health and surveillance · 2025Article
- Relating Biopsychosocial Meanings to Semi-Quantitative CRP Readings Among Primary Healthcare Users: Trends from a Cross-Sectional Study Analysis.Journal of clinical medicine · 2025Article
- The Impact of Digital Technology-Based Exercise Combined With Dietary Intervention on Body Composition in College Students With Obesity: Prospective Study.Journal of medical Internet research · 2025Article
- Identification of optimal cutoffs for obesity and lipid-related indices in screening activities of daily living disability in Chinese middle-aged and elderly adults.Frontiers in nutrition · 2025Article
- Titanium Dioxide Nanoparticle Exposure Provokes Greater Lung Inflammation in Females Than Males in the Context of Obesity.International journal of nanomedicine · 2025Article
- Association between body mass index and long-term all-cause mortality in critically ill patients without malignant tumors.PloS one · 2025Article
- More evidence of the health risks of normal weight obesity: the association with systemic inflammation.Frontiers in medicine · 2025Article
- NMR spectroscopy derived plasma biomarkers of inflammation in human populations: Influences of age, sex and adiposity.PloS one · 2025Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
Abstract
Chronic inflammation is an important pathway for obesity to harm health, the aggravation of chronic inflammation occurs without clinical symptoms. BMI is closely related to chronic inflammation, and it is a predictive factor of chronic inflammation, but the following questions remain unanswered: Are the effects of chronic inflammation on different BMI intervals consistent? Are the effects of BMI on chronic inflammation consistent between male and female? This study aimed to explore the threshold effect, and sex characteristics of the relationship between chronic inflammation and BMI.
methodsPeople with normal weight, overweight, and obesity were selected as subjects for cross-sectional study. BMI, hs-CRP, adiponectin and irisin was tested. Multiple regression analysis and generalized additive models were used to examine the association between hs-CRP and BMI.
results119 adults were recruited (normal weight: n = 30, 28.1 ± 7.65 years, BMI: 22.04 ± 1.55; overweight: n = 29, 27.45 ± 7.47 years, BMI: 26.11 ± 1.22; and obesity: n = 60, 28.82 ± 6.05 years, BMI: 33.68 ± 3.57). After adjusting for age and sex, BMI was found to be positively associated with the chronic inflammatory marker hs-CRP (β = 0.45; P < 0.001), which had a threshold effect on hs-CRP. Positive correlation with hs-CRP was observed for BMI of > 24.6 (β = 0.54; P < 0.001) but not for BMI of 18.5-25.4 (β = -0.02; P > 0.05). The pro-inflammatory effect caused by BMI increase in female (β = 0.56; P < 0.001) was higher than that in male (β = 0.38; P < 0.001). When BMI was greater than 33, a positive correlation with hs-CRP was observed in female (β = 0.97; P < 0.001) but not in male (β = 0.14; P > 0.05).
conclusionsBMI has a threshold effect on chronic inflammation, BMI greater than 24.3 is positively correlated with hs-CRP. BMI in 18.5-24.3 is not correlated with hs-CRP. Furthermore, when the BMI greater than 33, hs-CRP is not positively correlated with BMI in male, whereas the pro-inflammatory effect of BMI increase becomes greater in female. HIGHLIGHTS: • BMI has a threshold effect on chronic inflammation. BMI in 18.5-24.3 is not correlated with chronic inflammation, and BMI greater than 24.3 is positively correlated with chronic inflammation. • The pro-inflammatory effect caused by BMI increase in female is higher than that in male. In particular, when the BMI is greater than 33, chronic inflammation is not positively correlated with BMI in male, whereas the pro-inflammatory effect of BMI increase becomes greater in female.
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