Evidence map›Paper›PMID 37582630›Full record

ArticleThorax2024

Prospective study of e-cigarette use and respiratory symptoms in adolescents and young adults.

Alayna P Tackett, Robert Urman, Jessica Barrington-Trimis, Feifei Liu, Hanna Hong, Mary Ann Pentz, Talat S Islam, Sandrah P Eckel, Meghan Rebuli, Adam Leventhal and 3 more

Open access · greenAbstract read
In one paragraph

Article in Thorax, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 2 pooled it
7.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Why Adolescents Choose to Stop or Never Start Vaping: Evidence From South Africa.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2026
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  16. Frontiers in cellular and infection microbiology · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 6 institutions in 1 country.

Alayna P TackettDepartment of Internal Medicine, Division of Medical Oncology, Center for Tobacco Research, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.ORCID 0000-0003-3818-141X
Robert UrmanDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Jessica Barrington-TrimisDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Feifei LiuDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Hanna HongDivision of Pulmonology, Children's Hospital of Orange County, Orange, California, USA.
Mary Ann PentzDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Talat S IslamDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.ORCID 0000-0002-2837-865X
Sandrah P EckelDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Meghan RebuliDepartment of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, Chapel Hill, North Carolina, USA.
Adam LeventhalDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA.
Jonathan M SametDepartment of Epidemiology, Colorado School of Public Health, Aurora, Colorado, USA.
Kiros BerhaneDepartment of Biostatistics, Columbia University, New York, New York, USA.
Rob McConnellDepartment of Population and Public Health Sciences, University of Southern California Keck School of Medicine, Los Angeles, California, USA rmcconne@usc.edu.
University of Southern California · USChildren's Hospital of Orange County · USColorado School of Public Health · USColumbia University · USThe Ohio State University Wexner Medical Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4M
USC Tobacco Center of Regulatory ScienceU54CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jessica Louise Barrington-Trimis · 2018 to 2026
$39.0M
USC Tobacco Center of Regulatory Science (TCORS) for Vulnerable PopulationsP50CA180905 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PENTZ, MARY ANN, SAMET, JONATHAN M · 2013 to 2017
$20.1M
Translation CoreP2CES033433 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Jill E Johnston · 2022 to 2026
$4.9M
Understanding Transitions from Vaping to Smoking Across AdolescenceK01DA042950 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BARRINGTON-TRIMIS, JESSICA LOUISE · 2017 to 2021
$1.0M
Respiratory effects of E-Cigarette use among Youth: A prospective, longitudinal investigationK01HL148907 · NHLBI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TACKETT, ALAYNA PAULINE · 2019 to 2023
$981k
Diacetyl in e-cigarette flavorings: Acute and subacute pulmonary effectsR21HD084812 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MCCONNELL, ROB S · 2015 to 2016
$457k
NCI NIH HHS P50 CA180905NCI NIH HHS U54 CA180905NHLBI NIH HHS K01 HL148907NICHD NIH HHS R21 HD084812NIDA NIH HHS K01 DA042950NIEHS NIH HHS P2C ES033433NIEHS NIH HHS P30 ES007048NIH HHS P50CA180905, R21HD084812, K01DA042950, K01HL148907, P30ES007048, P2CES033433
6 · The paper itself

Abstract

rationaleElectronic cigarette (e-cigarette) aerosol contains volatile aldehydes, including flavourings and oxidant metals with known pulmonary toxicity.

objectivesTo evaluate the associations of e-cigarette use with symptoms of wheeze, bronchitic symptoms and shortness of breath (SOB) across 4 years of prospective data.

methodsParticipants completed questionnaires on respiratory symptoms and past 30-day e-cigarette, cigarette and cannabis use in 2014 (wave 1; N=2094; mean age 17.3 years, SD=0.6 years). Follow-up information was collected in 2015 (wave 2; n=1609), 2017 (wave 3; n=1502) and 2018 (wave 4; n=1637) using online surveys. Mixed-effects logistic regression models evaluated associations of e-cigarette use with respiratory symptoms. MEASUREMENTS AND MAIN

resultsParticipants were mostly Hispanic white (51.8%) and evenly representative by sex (49.6% female; 50.4% male). Compared with never e-cigarette users, past 30-day e-cigarette users reported increased odds of wheeze (OR 1.81; 95% CI 1.28, 2.56), bronchitic symptoms (OR 2.06; 95% CI 1.58, 2.69) and SOB (OR 1.78; 95% CI 1.23, 2.57), adjusting for study wave, age, sex, race, lifetime asthma diagnosis and parental education. Effect estimates were attenuated (wheeze (OR 1.41; 95% CI 0.99, 2.01), bronchitic symptoms (OR 1.55; 95% CI 1.18, 2.05), SOB (OR 1.48; 95% CI 1.01, 2.18)), after adjusting additionally for current cigarette use, cannabis use and secondhand exposure to e-cigarettes/cigarettes/cannabis.

conclusionsE-cigarette use in young adults was associated with respiratory symptoms, independent of combustible cannabis and cigarette exposures.

Indexed as

Electronic Nicotine Delivery SystemsTobacco ProductsVapingAdolescentDyspneaFemaleHumansMaleProspective StudiesRespiratory SoundsSurveys and QuestionnairesYoung AdultTobacco and the lung

Identifiers

PMID37582630
PMCPMC11062480
OpenAlexW4385828697

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.