Evidence map›Paper›PMID 37582616›Full record

ArticleNeurology(R) neuroimmunology & neuroinflammation2023

LGI1 Encephalitis and IgG4-Related Disease: Rare Conditions Collide.

Aaron Jesuthasan, Tara Barwick, Luke Dixon, Sophie Molloy, Michael R Johnson, James A P Tomlinson

Erratum issuedOpen access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology(R) neuroimmunology & neuroinflammation, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 citations in OpenAlex.

  1. Article
  2. Missing Full Disclosures.Neurology(R) neuroimmunology & neuroinflammation · 2025
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Aaron JesuthasanFrom the Charing Cross Hospital (A.J.); Department of Radiology (T.B.), Imperial College Healthcare NHS Trust, London, United Kingdom; Department of Surgery and Cancer (L.D.), Faculty of Medicine, Imperial College London, United Kingdom; London North West University Healthcare NHS Trust (S.M.); Department of Brain Sciences (M.R.J.), Faculty of Medicine, Imperial College London; and Renal Department (J.A.P.T.), Imperial College Healthcare NHS Trust, London, United Kingdom. aaronjesuthasan@gmail.com.
Tara BarwickFrom the Charing Cross Hospital (A.J.); Department of Radiology (T.B.), Imperial College Healthcare NHS Trust, London, United Kingdom; Department of Surgery and Cancer (L.D.), Faculty of Medicine, Imperial College London, United Kingdom; London North West University Healthcare NHS Trust (S.M.); Department of Brain Sciences (M.R.J.), Faculty of Medicine, Imperial College London; and Renal Department (J.A.P.T.), Imperial College Healthcare NHS Trust, London, United Kingdom.
Luke DixonFrom the Charing Cross Hospital (A.J.); Department of Radiology (T.B.), Imperial College Healthcare NHS Trust, London, United Kingdom; Department of Surgery and Cancer (L.D.), Faculty of Medicine, Imperial College London, United Kingdom; London North West University Healthcare NHS Trust (S.M.); Department of Brain Sciences (M.R.J.), Faculty of Medicine, Imperial College London; and Renal Department (J.A.P.T.), Imperial College Healthcare NHS Trust, London, United Kingdom.
Sophie MolloyFrom the Charing Cross Hospital (A.J.); Department of Radiology (T.B.), Imperial College Healthcare NHS Trust, London, United Kingdom; Department of Surgery and Cancer (L.D.), Faculty of Medicine, Imperial College London, United Kingdom; London North West University Healthcare NHS Trust (S.M.); Department of Brain Sciences (M.R.J.), Faculty of Medicine, Imperial College London; and Renal Department (J.A.P.T.), Imperial College Healthcare NHS Trust, London, United Kingdom.
Michael R JohnsonFrom the Charing Cross Hospital (A.J.); Department of Radiology (T.B.), Imperial College Healthcare NHS Trust, London, United Kingdom; Department of Surgery and Cancer (L.D.), Faculty of Medicine, Imperial College London, United Kingdom; London North West University Healthcare NHS Trust (S.M.); Department of Brain Sciences (M.R.J.), Faculty of Medicine, Imperial College London; and Renal Department (J.A.P.T.), Imperial College Healthcare NHS Trust, London, United Kingdom.
James A P TomlinsonFrom the Charing Cross Hospital (A.J.); Department of Radiology (T.B.), Imperial College Healthcare NHS Trust, London, United Kingdom; Department of Surgery and Cancer (L.D.), Faculty of Medicine, Imperial College London, United Kingdom; London North West University Healthcare NHS Trust (S.M.); Department of Brain Sciences (M.R.J.), Faculty of Medicine, Imperial College London; and Renal Department (J.A.P.T.), Imperial College Healthcare NHS Trust, London, United Kingdom.
Imperial College Healthcare NHS Trust · GBImperial College London · GBLondon North West Healthcare NHS Trust · GB

Funding

Medical Research Council MR/S02638X/1
6 · The paper itself

Abstract

objectivesLeucine-rich glioma-inactivated 1 (LGI1) encephalitis and IgG4-related disease (IgG4RD) have traditionally been regarded as 2 distinct disease entities.

methodsWe detail the presentation, investigations, and management of a patient who showed typical signs and symptoms of LGI1 encephalitis and also found to possess pancreatic changes and a serum profile in keeping with IgG4RD.

resultsSerum and CSF analyses at presentation showed a significant hyponatraemia (117 mmol/L), elevated IgG4 concentration (1.73 g/L), and the presence of LGI1 antibodies. MRI revealed symmetrical diffuse T2-weighted hyperintensity and mild swelling throughout both medial temporal lobes. CT of the chest, abdomen and pelvis revealed an edematous, bulky pancreas with loss of lobulation, typical for IgG4RD. A glucocorticoid weaning regimen was commenced, facilitated by 2 rituximab infusions, with the patient showing an effective treatment response. HLA testing confirmed the presence of HLA DRB1 and HLA DQB1 risk alleles. DISCUSSION: This case suggests that there may be shared mechanisms between LGI1 encephalitis and IgG4RD, supported by common risk HLA associations and treatment strategies/responses. To our knowledge, this represents the first instance that LGI1 encephalitis and IgG4RD have been reported in the same patient and emphasizes the continued development of our understanding of the wide range of IgG4-mediated conditions.

Indexed as

EncephalitisImmunoglobulin G4-Related DiseaseAutoantibodiesHumansImmunoglobulin GIntracellular Signaling Peptides and ProteinsLeucineAutoantibodiesImmunoglobulin GIntracellular Signaling Peptides and ProteinsLeucineLGI1 protein, human

Identifiers

PMID37582616
PMCPMC10427142
OpenAlexW4385828968

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.