Evidence map›Paper›PMID 37582374›Full record

ArticleCurrent biology : CB2023

Centromere-specifying nucleosomes persist in aging mouse oocytes in the absence of nascent assembly.

Arunika Das, Katelyn G Boese, Kikue Tachibana, Sung Hee Baek, Michael A Lampson, Ben E Black

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Centromere regulation in the germline and early embryo.Current opinion in genetics & development · 2025
    Review
  4. A brief historical perspective on cell cycle control of CENP-A assembly and inheritance.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2025
    Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Arunika DasDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Department of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.
Katelyn G BoeseDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.
Kikue TachibanaDepartment of Totipotency, Max Planck Institute of Biochemistry, Martinsried 82152, Germany.
Sung Hee BaekCreative Research Initiatives Center for Epigenetic Code and Diseases, Seoul National University, Seoul 08826, Republic of Korea.
Michael A LampsonDepartment of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Center for Genome Integrity, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: lampson@sas.upenn.edu.
Ben E BlackDepartment of Biochemistry and Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA; Epigenetics Institute, University of Pennsylvania, Philadelphia, PA 19104, USA; Penn Center for Genome Integrity, University of Pennsylvania, Philadelphia, PA 19104, USA. Electronic address: blackbe@pennmedicine.upenn.edu.
Penn Center for AIDS Research · USUniversity of Pennsylvania · USMax Planck Institute of Biochemistry · DESeoul National University · KR

Funding

Age and molecular mechanisms contributing to aneuploidy in oocytesR01HD058730 · NICHD · UNIVERSITY OF PENNSYLVANIA · PI BLACK, BEN E., LAMPSON, MICHAEL · 2009 to 2020
$3.2M
NICHD NIH HHS R01 HD058730
6 · The paper itself

Abstract

Centromeres direct genetic inheritance but are not themselves genetically encoded. Instead, centromeres are defined epigenetically by the presence of a histone H3 variant, CENP-A.

Indexed as

Chromosomal Proteins, Non-HistoneNucleosomesAgingAnimalsAutoantigensCentromereCentromere Protein AChromatinFemaleMammalsMiceOocytesAutoantigensCentromere Protein AChromatinChromosomal Proteins, Non-HistoneNucleosomescentromeresmeiosisnucleosomesoocytesprotein stabilityreproductive aging

Identifiers

PMID37582374
PMCPMC10528140
OpenAlexW4385813814

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.