Evidence map›Paper›PMID 37582373›Full record

ArticleCurrent biology : CB2023

Behavioral measurements of motor readiness in mice.

Elise N Mangin, Jian Chen, Jing Lin, Nuo Li

Abstract read
In one paragraph

Article in Current biology : CB, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Separating cognitive and motor processes in the behaving mouse.bioRxiv : the preprint server for biology · 2024
    Article
  6. Differential Formation of Motor Cortical Dynamics during Movement Preparation According to the Predictability of Go Timing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Elise N ManginDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Jian ChenDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Jing LinDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA.
Nuo LiDepartment of Neuroscience, Baylor College of Medicine, Houston, TX 77030, USA. Electronic address: nuol@bcm.edu.

Funding

Multi-regional neural circuit dynamics underlying short-term memoryR01NS113110 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DRUCKMANN, SHAUL, LI, NUO · 2019 to 2023
$3.2M
Cortico-cerebellar interactions underlying motor planning and movementR01NS112312 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI LI, NUO · 2019 to 2023
$1.8M
Multi-regional neural circuit dynamics underlying short-term memoryR21NS104781 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI DRUCKMANN, SHAUL, LI, NUO · 2017 to 2018
$448k
NINDS NIH HHS R01 NS112312NINDS NIH HHS R01 NS113110NINDS NIH HHS R21 NS104781
6 · The paper itself

Abstract

Motor planning facilitates rapid and precise execution of volitional movements. Although motor planning has been classically studied in humans and monkeys, the mouse has become an increasingly popular model system to study neural mechanisms of motor planning. It remains yet untested whether mice and primates share common behavioral features of motor planning. We combined videography and a delayed response task paradigm in an autonomous behavioral system to measure motor planning in non-body-restrained mice. Motor planning resulted in both reaction time (RT) savings and increased movement accuracy, replicating classic effects in primates. We found that motor planning was reflected in task-relevant body features. Both the specific actions prepared and the degree of motor readiness could be read out online during motor planning. The online readout further revealed behavioral evidence of simultaneous preparation for multiple actions under uncertain conditions. These results validate the mouse as a model to study motor planning, demonstrate body feature movements as a powerful real-time readout of motor readiness, and offer behavioral evidence that motor planning can be a parallel process that permits rapid selection of multiple prepared actions.

Indexed as

MovementPsychomotor PerformanceAnimalsHumansMiceReaction TimeUncertaintyVolitiondelayed response taskdynamic motor planninglickingmicemotor behaviormotor planningreachinguncertainty

Identifiers

PMID37582373
PMCPMC10529875

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.