Evidence map›Paper›PMID 37582174›Full record

ArticleReproduction & fertility2023

Presence of KREMEN receptors for DKK1 in the preimplantation bovine embryo.

Thiago Fernandes Amaral, Yao Xiao, Surawich Jeensuk, Tatiane Silva Maia, Camila J Cuellar, Chloe A Gingerich, Tracy L Scheffler, Peter J Hansen

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Reproduction & fertility, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Thiago Fernandes AmaralT Amaral, Animal Sciences, University of Florida, Gainesville, United States.
Yao XiaoY Xiao, Key Laboratory of Livestock and Poultry Multi-omics of MARA, Shandong Academy of Agricultural Sciences, Jinan, China.
Surawich JeensukS Jeensuk, Dept of Animal Sciences, University of Florida, Gainesville, United States.
Tatiane Silva MaiaT Maia, Animal Sciences, University of Florida, Gainesville, United States.
Camila J CuellarC Cuellar, Dept of Animal Sciences, University of Florida, Gainesville, United States.
Chloe A GingerichC Gingerich, Dept of Animal Sciences, University of Florida, Gainesville, United States.
Tracy L SchefflerT Scheffler, Dept of Animal Sciences, University of Florida, Gainesville, United States.
Peter J HansenP Hansen, Dept. of Animal Sciences, University of Florida, Gainesville, 32611-0910, United States.
University of Florida · USShandong Academy of Agricultural Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The WNT inhibitory protein DKK1 has been shown to regulate development of the preimplantation embryo to the blastocyst stage. In cattle, DKK1 increases the number of trophectoderm cells that are the precursor of the placenta. DKK1 can affect cells by blocking WNT signaling through its receptors KREMEN1 and KREMEN2. Here it was shown that the mRNA for KREMEN1 and KREMEN2 decline as the embryo advances in development. Nonetheless, immunoreactive KREMEN1 was identified in blastocysts using Western blotting. DKK1 also decreased amount of immunoreactive CTNNB1 in blastocysts, as would be expected if DKK1 was signaling through a KREMEN-mediated pathway. Thus, it is likely that KREMEN1 functions as a receptor for DKK1 in the preimplantation bovine embryo.

Identifiers

PMID37582174
PMCPMC10620448
OpenAlexW4385830331

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.