Evidence map›Paper›PMID 37581854›Full record

ReviewResearch on child and adolescent psychopathology2023

Challenges with Latent Variable Approaches to Operationalizing Dimensions of Childhood adversity - a Commentary on Sisitsky et al. (2023).

Katie A McLaughlin, David G Weissman, John Flournoy

Erratum issuedAbstract readReview
PubMed Publisher
In one paragraph

Review in Research on child and adolescent psychopathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Research Review: Assessment of early-life adversity and trauma - cumulative risk and dimensional approaches.Journal of child psychology and psychiatry, and allied disciplines · 2025
    Review
  4. Review
  5. Article
  6. Article
  7. Family Functioning and Pubertal Maturation in Hispanic/Latino Children from the HCHS/SOL Youth.International journal of environmental research and public health · 2025
    Article
  8. Article
  9. Article
  10. Article
  11. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Katie A McLaughlinDepartment of Psychology, Harvard University, 33 Kirkland Street, 02138, Cambridge, MA, USA.
David G WeissmanDepartment of Psychology, Harvard University, 33 Kirkland Street, 02138, Cambridge, MA, USA. dweissman@fas.harvard.edu.ORCID 0000-0001-9966-3338
John FlournoyDepartment of Psychology, Harvard University, 33 Kirkland Street, 02138, Cambridge, MA, USA.

Funding

Neurodevelopmental Mechanisms Underlying Stress Vulnerability during AdolescenceR37MH119194 · NIMH · HARVARD UNIVERSITY · PI Katie McLaughlin · 2020 to 2026
$10.6M
Child Trauma and the Development of Neural Systems Underlying Emotion RegulationR01MH103291 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2014 to 2018
$3.8M
Deprivation and Threat: Dimensions of Early Experience and Neural DevelopmentR01MH106482 · NIMH · UNIVERSITY OF WASHINGTON · PI MCLAUGHLIN, KATIE · 2016 to 2020
$3.1M
Neurodevelopmental Mechanisms Underlying Stress Vulnerability during AdolescenceR56MH119194 · NIMH · HARVARD UNIVERSITY · PI MCLAUGHLIN, KATIE · 2019 to 2019
$1.5M
Emotional Awareness: An integrative neural mechanism linking childhood trauma with psychopathologyK99MH127248 · NIMH · HARVARD UNIVERSITY · PI WEISSMAN, DAVID G · 2022 to 2023
$246k
NIMH NIH HHS K99 MH127248NIMH NIH HHS K99-MH127248NIMH NIH HHS R01-MH103291NIMH NIH HHS R01-MH106482NIMH NIH HHS R37-MH119194NIMH NIH HHS R56-MH119194
6 · The paper itself

Abstract

Childhood adversity is a common, powerful risk factor for future mental and physical health problems. Appropriately aggregating and categorizing discrete adverse experiences into cumulative indices remains an active area of research and debate in the field of developmental psychopathology. In a recent article by Sisitsky et al. (2013), they report using confirmatory factor analysis and latent profile analysis to categorize participants into "profiles" of childhood adversity. In this commentary, we argue that categorizing dimensions or profiles of childhood adversity based on the tendency of adversities to co-occur is misaligned with dimensional models of adversity, which derive underlying dimensions from their tendency to cumulatively predict certain outcomes rather than adversity co-occurrence. We summarize the history of theories and methods of operationalizing childhood adversity that led to the development of the dimensional model of adversity and psychopathology. We then explain why latent variable approaches, which simply reflect the tendency of adverse experiences to co-occur, are inappropriate for validating any given approach.

Indexed as

Adverse Childhood ExperiencesFactor Analysis, StatisticalHumansPsychopathologyRisk FactorsChildhood adversityDeprivationDimensional modelFactor analysisThreat

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.