Evidence map›Paper›PMID 37581719›Full record

ArticleClinical journal of gastroenterology2023

A case of hepatosplenic cat scratch disease with hemophagocytic lymphohistiocytosis.

Daisuke Minezaki, Mizuki Endo, Tomoko Saito, Tomoko Tokumaru, Masao Iwao, Mie Arakawa, Koichi Honda, Kazuhiro Mizukami, Masaaki Kodama, Kazunari Murakami

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In one paragraph

Article in Clinical journal of gastroenterology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Daisuke MinezakiDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Mizuki EndoDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan. emizuki@oita-u.ac.jp.ORCID http://orcid.org/0000-0002-3558-0071
Tomoko SaitoDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Tomoko TokumaruDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Masao IwaoDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Mie ArakawaDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Koichi HondaDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Kazuhiro MizukamiDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Masaaki KodamaDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Kazunari MurakamiDepartment of Gastroenterology, Oita University, 1-1 Idaigaoka, Hasama, Yufu, Oita, 879-5593, Japan.
Oita University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cat scratch disease (CSD) is associated with Bartonella henselae (B. henselae) infection caused by cat scratches or bites. It typically presents with lymphadenitis and fever. However, there are atypical cases such as hepatosplenic CSD, which presents with specific lesions in the liver and spleen. Hemophagocytic lymphohistiocytosis (HLH) is a rare and severe multisystem disorder triggered by infections, cancers, or autoimmune diseases. We experienced a rare case of hepatosplenic CSD with HLH in a non-immunocompromised adult. A 78-year-old woman complained of fever and fatigue. Laboratory tests revealed anemia and liver dysfunction; abdominal contrast-enhanced computed tomography (CT) revealed splenomegaly and nodular hypodense areas in the spleen. In addition, the levels of ferritin and serum soluble IL-2R were markedly elevated, so clinical diagnosis of HLH was made. Positron emission tomography/CT revealed diffuse fluorodeoxyglucose uptake in the liver and spleen suggesting malignant lymphoma, while the pathological findings from liver biopsy suggested infectious diseases. Although she had no cat bites and scratches, she had many cats; therefore, serum B. henselae antibody titers were measured. The B. henselae IgG and IgM titer were 1:128 and 1:20; thus, she was diagnosed with hepatosplenic CSD. Patients with hepatosplenic nodular lesions and contact with cats should be considered for this disease.

Indexed as

Bartonella henselaeCat-Scratch DiseaseLiver DiseasesLymphohistiocytosis, HemophagocyticAdultAgedAnimalsAntibodies, BacterialCatsFemaleHumansAntibodies, BacterialBartonella henselaeHemophagocytic lymphohistiocytosisHepatosplenic cat scratch disease

Identifiers

PMID37581719
OpenAlexW4385827178

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.