Evidence map›Paper›PMID 37581718›Full record

ArticleJournal of autism and developmental disorders2024

Adaptive Skills of Individuals with Angelman Syndrome Assessed Using the Vineland Adaptive Behavior Scales, 2nd Edition.

Angela Gwaltney, Sarah Nelson Potter, Sarika U Peters, Rene L Barbieri-Welge, Lucia T Horowitz, Lisa M Noll, Rachel J Hundley, Lynne M Bird, Wen-Hann Tan, Anjali Sadhwani and 1 more

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Caregiver Meaningful Score Differences and Meaningful Score Regions for the Observer-Reported Communication Ability Measure for Individuals with Angelman Syndrome.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Angela Gwaltney *RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-2305-7187
Sarah Nelson Potter *RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-8640-8992
Sarika U PetersDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.
Rene L Barbieri-WelgeDevelopmental Evaluation Clinic, Rady Children's Hospital-San Diego, San Diego, CA, USA.
Lucia T HorowitzGreenwood Genetic Center, Greenwood, SC, USA.
Lisa M NollTexas Children's Hospital, Houston, TX, USA.
Rachel J HundleyDepartment of Pediatrics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID http://orcid.org/0000-0001-5934-7832
Lynne M BirdDivision of Dysmorphology/Genetics, Rady Children's Hospital-San Diego, San Diego, CA, USA.ORCID http://orcid.org/0000-0003-4833-3747
Wen-Hann TanDivision of Genetics and Genomics, Boston Children's Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-1593-6149
Anjali Sadhwani *Department of Psychiatry and Behavioral Sciences, Boston Children's Hospital, 300 Longwood Ave, Boston, MA, 02446, USA. anjali.sadhwani@childrens.harvard.edu.ORCID http://orcid.org/0000-0003-0938-0591
Anne Wheeler *RTI International, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0003-2693-5616

Funding

Training and Career Development ComponentU54HD061222 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI PERCY, ALAN KENNETH · 2009 to 2019
$12.4M
Overall: Eunice Kennedy Shriver Intellectual and Developmental Disabilities Research Center at VanderbiltP50HD103537 · NICHD · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Jeffrey L Neul · 2020 to 2026
$10.3M
RARE DISEASE CRC FOR NEW THERAPIES AND NEW DIAGNOSTICSU54RR019478 · NCRR · BAYLOR COLLEGE OF MEDICINE · PI BEAUDET, ARTHUR L. · 2003 to 2008
$7.3M
NCRR NIH HHS U54 RR019478NICHD NIH HHS P50 HD103537NICHD NIH HHS U54 HD061222
6 · The paper itself

Abstract

In the current study, we examined adaptive skills and trajectories over time in 257 individuals with Angelman syndrome (AS) using the Vineland Adaptive Behavior Scales, 2nd Edition. Multilevel linear models were used to examine differences between molecular subtypes over time, from one year to 13 years of age, in the adaptive domains of communication, daily living skills, socialization and motor skills. Individuals with non-deletion subtypes typically demonstrated a higher level of adaptive skills compared to those with deletion subtypes. Statistically significant growth was observed in all adaptive domains through at least early adolescence. Individuals with AS should continue to receive developmental services and educational supports through adolescence and into adulthood given the slow rates of growth being observed across adaptive domains.

Indexed as

Adaptation, PsychologicalAngelman SyndromeActivities of Daily LivingAdolescentChildChild, PreschoolCommunicationFemaleHumansInfantMaleMotor SkillsSocializationActivities of daily livingDevelopmental disabilitiesLanguage disordersMotor impairmentsNeurodevelopmental disordersSocial impairments

Identifiers

PMID37581718
PMCPMC10867286

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.