Evidence map›Paper›PMID 37581527›Full record

ArticlePharmaceutical nanotechnology2024

Preparation, Physicochemical Characterization, and Stability Study of

Carlos Andrés Benitez-Llano, Oscar Albeiro Florez-Acosta, Darsy Dayana Velasquez-Polo, Ana Cecilia Mesa-Arango, Carolina Zapata-Zapata

Abstract read
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In one paragraph

Article in Pharmaceutical nanotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 4 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Carlos Andrés Benitez-LlanoDepartment of Pharmacy, Group for the Design and Formulation of Medicines, Cosmetics and Related Products (DYFOMECO), Faculty of Pharmaceutical and Food Sciences, University of Antioquia, Medellín, Colombia.ORCID 0009-0005-6777-6684
Oscar Albeiro Florez-AcostaDepartment of Pharmacy, Group for the Design and Formulation of Medicines, Cosmetics and Related Products (DYFOMECO), Faculty of Pharmaceutical and Food Sciences, University of Antioquia, Medellín, Colombia.ORCID 0000-0002-6914-0891
Darsy Dayana Velasquez-PoloDepartment of Pharmacy, Group for the Design and Formulation of Medicines, Cosmetics and Related Products (DYFOMECO), Faculty of Pharmaceutical and Food Sciences, University of Antioquia, Medellín, Colombia.ORCID 0009-0007-1614-6994
Ana Cecilia Mesa-ArangoDepartment of Mycology, Clinical Epidemiology Academic Group, Faculty of Medicine, University of Antioquia, Medellín, Colombia.ORCID 0000-0002-6183-0564
Carolina Zapata-ZapataDepartment of Mycology, Clinical Epidemiology Academic Group, Faculty of Medicine, University of Antioquia, Medellín, Colombia.ORCID 0000-0001-7694-3978
Universidad de Antioquia · CO

Funding

Ministerio de Ciencia, Tecnología e Innovación, Ministerio de Educación Nacional, Ministerio de Industria, Comercio y Turismo, and ICETEX Grant RC-FP44842-212- 2018
6 · The paper itself

Abstract

introductionFungal diseases are a priority in research, development, and health care, according to the WHO, mainly due to

methodsNanoemulsions were obtained using a high energy high shear method. Their particle size distribution, Z potential, viscosity, pH, encapsulation efficiency (EE), thermodynamic stability and the Turbiscan Stability Index (TSI) were evaluated. The nanoemulsion prototype was adjusted to improve performance characteristics and microbiological efficacy. Thymol was used as an analyte in the EO quantification using UHPLC-DAD.

resultsAn O/W nanoemulsion with hydrodynamic diameter <200 nm and polydispersity index <0.3, EE >95%, with TSI < 1.5, anti-

conclusionA pharmaceutical formulation prototype is obtained that maintains the physical and physicochemical characteristics over time. Permeability is verified in an

Indexed as

Antifungal AgentsDrug StabilityEmulsionsLippiaOils, VolatileParticle SizeAdministration, TopicalCandida albicansDrug Delivery SystemsNanoparticlesPermeabilitySolubilityThymolViscosityAntifungal AgentsEmulsionsOils, VolatileThymolCandida albicans.essential oilLippia origanoidesNanoemulsionpermeabilitystabilitythymol

Identifiers

PMID37581527
OpenAlexW4385827353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.