Trial reportJournal of the American Heart Association2023
Plasma Trimethylamine-
Open access · goldAbstract readClinical Trial
In one paragraph
Trial report in Journal of the American Heart Association, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 4% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.
- Impacts of intestinal microbiota metabolite trimethylamine N-oxide on cardiovascular disease: a bibliometric analysis.Frontiers in microbiology · 2024Pooled it
- The association between trimethylamine N-oxide levels and ischemic stroke occurrence: a meta-analysis and Mendelian randomization study.BMC neurology · 2023Pooled it
- Trimethylamine N-oxide and major adverse cardiac and cerebrovascular events: results of umbrella review and meta-analysis.Nutrition & metabolism · 2026Article
- From Fecal Microbial Potential to Circulating Trimethylamine N-oxide and Cardiovascular Events: A Narrative Review.Cureus · 2026Review
- Gut microbial trimethylamine N-oxide generation promotes risk of atrial fibrillation via muscarinic receptor-mediated autonomic dysfunction.The Journal of clinical investigation · 2026Article
- Resveratrol and Curcumin in Stroke Therapy: From Experimental Evidence to Clinical Perspectives.Nutrients · 2026Review
- Gut microbe-generated metabolite trimethylamine N-oxide and risk of abdominal aortic aneurysm: a cohort study.European heart journal · 2026Article
- Brain-gut communication and potential applications of microecological treatments in stroke.Frontiers in neuroscience · 2026Review
- Trimethylamine N-oxide (TMAO) for risk stratification after acute ischemic stroke: Results from the BIOSIGNAL cohort study.European stroke journal · 2026Article
- Article
- Trimethylamine N-oxide (TMAO) for risk stratification after acute ischemic stroke: Results from the BIOSIGNAL cohort study.European stroke journal · 2025Article
- Trimethylamine-N-oxide (TMAO) and risk of incident cardiovascular events in the multi ethnic study of Atherosclerosis.Scientific reports · 2025Article
- The gut microbiota in thrombosis.Nature reviews. Cardiology · 2025Review
- The Interplay of Diet, Genome, Metabolome, and Gut Microbiome in Cardiovascular Disease: A Narrative Review.Current medicinal chemistry · 2025Review
- Gut microbiome and inflammation in cardiovascular drug response: trends in therapeutic success and commercial focus.Inflammopharmacology · 2025Review
- Microbiome-Derived Trimethylamine N-Oxide (TMAO) as a Multifaceted Biomarker in Cardiovascular Disease: Challenges and Opportunities.International journal of molecular sciences · 2024Review
- Gut Microbe-Generated Metabolite Trimethylamine-N-Oxide and Ischemic Stroke.Biomolecules · 2024Review
- Identification of Urine Metabolic Markers of Stroke Risk Using Untargeted Nuclear Magnetic Resonance Analysis.International journal of molecular sciences · 2024Article
- Artificial Sweeteners: A New Dietary Environmental Risk Factor for Atrial Fibrillation?Circulation. Arrhythmia and electrophysiology · 2024Article
- Trimethylamine N-oxide predicts cardiovascular events in coronary artery disease patients with diabetes mellitus: a prospective cohort study.Frontiers in endocrinology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 8 institutions in 1 country.
Rozenn N LemaitreCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USA.ORCID 0000-0002-7038-1844
Paul N JensenCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USA.ORCID 0000-0001-5836-821X
Zeneng WangDepartment of Cardiovascular & Metabolic Sciences Lerner Research Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-6455-8228
Amanda M FrettsDepartment of Epidemiology University of Washington Seattle WA USA.ORCID 0000-0002-5358-2345
Colleen M SitlaniCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USA.ORCID 0000-0001-7656-7482
Ina NemetDepartment of Cardiovascular & Metabolic Sciences Lerner Research Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0002-0657-7121
Nona SotoodehniaCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USA.ORCID 0000-0002-2705-6237
Marcia C de Oliveira OttoDivision of Epidemiology, Human Genetics and Environmental Science The University of Texas Health Science Center at Houston School of Public Health Houston TX USA.ORCID 0000-0002-4585-0688
Weifei ZhuDepartment of Cardiovascular & Metabolic Sciences Lerner Research Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0003-4355-134X
Matt BudoffDepartment of Medicine University of California at Los Angeles Los Angeles CA USA.ORCID 0000-0002-9616-1946
W T LongstrethDepartment of Neurology University of Washington Seattle WA USA.
Bruce M PsatyCardiovascular Health Research Unit, Department of Medicine University of Washington Seattle WA USA.ORCID 0000-0002-7278-2190
David S SiscovickNew York Academy of Medicine New York NY USA.ORCID 0000-0003-0461-175X
Stanley L HazenDepartment of Cardiovascular & Metabolic Sciences Lerner Research Institute, Cleveland Clinic Cleveland OH USA.ORCID 0000-0001-7124-6639
Dariush MozaffarianFriedman School of Nutrition Science and Policy Tufts University Boston MA USA.ORCID 0000-0001-7958-9492
University of Washington · USCleveland Clinic · USCleveland Clinic Lerner College of Medicine · USKaiser Permanente Washington Health Research Institute · USNew York Academy of Medicine · USThe University of Texas Health Science Center at Houston · USTufts University · USUniversity of California, Los Angeles · US
Funding
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1MWake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3MClinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2MSUBCLINICAL CARDIOVASCULAR DISEASE COORDINATING CENTERN01HC95159 · NHLBI · UNIVERSITY OF WASHINGTON · PI KRONMAL, RICHARD A · 2007 to 2014
$19.6MTask Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2MGut Flora Metabolism of Dietary Phosphatidylcholine and CVDR01HL103866 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L · 2010 to 2023
$10.8MExceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5MTMAO and Initiation, Extent, and Clinical Onset of Atherosclerotic CVDR01HL135920 · NHLBI · TUFTS UNIVERSITY BOSTON · PI Stanley L Hazen, DARIUSH MOZAFFARIAN · 2017 to 2026
$8.7MCARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC95160 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI WATSON, KAROL · 2007 to 2015
$7.7MAtrial fibrillation burden, vascular disease of the brain and cardiac MRI in MESAR01HL127659 · NHLBI · UNIVERSITY OF WASHINGTON · PI HECKBERT, SUSAN R · 2015 to 2018
$7.4MSUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC95164 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LIU, KIANG · 2007 to 2015
$7.0MNCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01HC55222NHLBI NIH HHS N01HC85079NHLBI NIH HHS N01HC85080NHLBI NIH HHS N01HC85081NHLBI NIH HHS N01HC85082NHLBI NIH HHS N01HC85083NHLBI NIH HHS N01HC85086NHLBI NIH HHS N01HC95159NHLBI NIH HHS N01HC95160NHLBI NIH HHS N01HC95161NHLBI NIH HHS N01HC95162NHLBI NIH HHS N01HC95163NHLBI NIH HHS N01HC95164NHLBI NIH HHS N01HC95165NHLBI NIH HHS N01HC95166NHLBI NIH HHS N01HC95167NHLBI NIH HHS N01HC95168NHLBI NIH HHS N01HC95169NHLBI NIH HHS R01 HL103866NHLBI NIH HHS R01 HL127659NHLBI NIH HHS R01 HL135920NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629
Abstract
Background The association of circulating trimethylamine-
Indexed as
AtherosclerosisIschemic StrokeStrokeAgedFemaleHumansMethylaminesOxidesProspective StudiesRisk FactorsUnited StatesMethylaminesOxidestrimethylaminetrimethyloxamineepidemiologyrisk factorsstrokeTMAO
Identifiers
What OpenQuestion holds
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LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.