ArticleCurrent neuropharmacology2024
The HPA Axis as Target for Depression.
Article in Current neuropharmacology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
66 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic narrative review of the form, process, and function of sensory hyposensitivity in depression.Translational psychiatry · 2026Pooled it
- Gut microbiota-dependent mechanisms and efficacy of natural polysaccharides in multitarget antidepressant therapy: a systematic review.Frontiers in psychiatry · 2026Pooled it
- Association between atherogenic index of plasma and depression in patients with type 2 diabetes mellitus: A cross-sectional study.Medicine · 2026Article
- The NO-cGMP signaling pathway and depression: mechanisms and therapeutic prospects.Molecular biology reports · 2026Review
- Recent Advances in the Brain-Gut Axis in the Development and Progression of Depression.Actas espanolas de psiquiatria · 2026Review
- Intermittent Fasting Exerts Antidepressant-Like Effects by Restoring HPA Axis Homeostasis Through Coordinated GR-MR Signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- From Iron to Depression: The Crosstalk Between the Periphery and Brain.Neuroscience bulletin · 2026Review
- Depression trajectory modifies the association between estimated glucose disposal rate and incident stroke: a prospective cohort study.BMC cardiovascular disorders · 2026Article
- Gender differences and risk factors for suicide attempts in first-episode drug-naïve psychotic versus non-psychotic major depression: a large cross-sectional study.European archives of psychiatry and clinical neuroscience · 2026Article
- Bergamot Essential Oil Beverage: Preparation, Formulation Optimization, and Preliminary Evaluation of Antidepressant-like Effects in Mice Induced by Chronic Corticosterone Treatment.Foods (Basel, Switzerland) · 2026Article
- Maternal depression symptoms as a context for longitudinal changes in the perinatal brain and infant emotion outcomes.Archives of women's mental health · 2026Article
- Pharmacotherapeutic Management of Depression in Patients With Cancer: A Review of Mechanistic and Clinical Evidence.Cancer reports (Hoboken, N.J.) · 2026Review
- The HPA axis and kynurenine pathway: exploring the role of stress and neuroinflammation in treatment-resistant depression.Pharmacological reports : PR · 2026Review
- Bisphenol S and Neurological Health: An Integrated Overview of Neurotoxicity and Underlying Mechanisms.Molecular neurobiology · 2026Review
- Acute stress induces changes in epigenome-wide DNA methylation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Aquaporin-4 Dysfunction in Depression: From Pathogenic Mechanisms to Novel Therapeutic Targeting.International journal of molecular sciences · 2026Review
- Inflammatory Cytokines as a Shared Pathophysiological Pathway in Depression and Chronic Insomnia: A Narrative Review of Mechanisms and Clinical Implications.Neuropsychiatric disease and treatment · 2026Review
- Establishment and investigation of a surgical model of hypothyroidism in Wistar rats.PloS one · 2026Article
- Chain mediating effect of somatic pain and sleep duration between chronic disease count and depressive symptoms in older adults.Frontiers in psychiatry · 2026Article
- Baicalin as a Multifunctional Candidate for Depression and Related Neuropsychiatric Comorbidities: From Neuroinflammation Modulation to Neuroplasticity Restoration.Drug design, development and therapy · 2026Review
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD) is a stress-related mental disorder with a lifetime prevalence of 20% and, thus, is one of the most prevalent mental health disorders worldwide. Many studies with a large number of patients support the notion that abnormalities of the hypothalamus-pituitaryadrenal (HPA) axis are crucial for the development of MDD. Therefore, a number of strategies and drugs have been investigated to target different components of the HPA axis: 1) corticotrophinreleasing hormone (CRH) 1 receptor antagonists; 2) vasopressin V
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.