Trial reportEuropean journal of psychotraumatology2023
A randomized controlled trial of Deep Brain Reorienting: a neuroscientifically guided treatment for post-traumatic stress disorder.
Trial report in European journal of psychotraumatology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Augmenting evidence-based PTSD psychotherapy with neuroscientifically informed interventions: A mind-body-brain approach.Journal of military, veteran and family health · 2026Article
- The COMPASS framework for chronic pain and posttraumatic stress disorder: navigating the transition from threat to safety through yoga.Frontiers in public health · 2026Article
- A predictive processing framework for body-oriented trauma intervention: a hypothesis illustrated by Body Connect Therapy.Frontiers in psychology · 2026Article
- The impact of trauma and how to intervene: a narrative review of psychotraumatology over the past 15 years.European journal of psychotraumatology · 2025Article
- Overcoming the Brain-Body Disconnect Following Attachment Trauma: A Comment on Farina and Schimmenti.Clinical neuropsychiatry · 2025Article
- The Psychopathological Domains of Attachment Trauma: A Commentary.Clinical neuropsychiatry · 2025Article
- Attachment Trauma Re-Viewed: A Commentary on Farina and Schimmenti (2025a).Clinical neuropsychiatry · 2025Article
- Evolving Psychotherapeutic Approaches for PTSD: Beyond the Fear-Based Model.Psychiatry and clinical psychopharmacology · 2025Article
- Verbal Abuse, Depersonalization, and the Innate Alarm and Defensive Systems: A Single Case Illustration of Treatment with Deep Brain Reorienting.Journal of child & adolescent trauma · 2025Article
- Neuroscience-based relational art therapy and deep brain reorienting in the treatment of dissociative identity disorder.Frontiers in psychology · 2025Article
- Reflecting onJournal of military, veteran and family health · 2024Article
- Article
- Treatment of dissociative identity disorder: leveraging neurobiology to optimize success.Expert review of neurotherapeutics · 2024Review
- A conceptual framework for a neurophysiological basis of art therapy for PTSD.Frontiers in human neuroscience · 2024Review
- The Stress Phenotyping Framework: A multidisciplinary biobehavioral approach for assessing and therapeutically targeting maladaptive stress physiology.Stress (Amsterdam, Netherlands) · 2024Review
- Celebrating 15 years of Psychotraumatology - a future with generative AI?European journal of psychotraumatology · 2024Article
- Survival, Attachment, and Healing: An Evolutionary Lens on Interventions for Trauma-Related Dissociation.Psychology research and behavior management · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdvanced neuroscientific insights surrounding post-traumatic stress disorder (PTSD) and its associated symptomatology should beget psychotherapeutic treatments that integrate these insights into practice. Deep Brain Reorienting (DBR) is a neuroscientifically-guided psychotherapeutic intervention that targets the brainstem-level neurophysiological sequence that transpired during a traumatic event. Given that contemporary treatments have non-response rates of up to 50% and high drop-out rates of >18%, DBR is investigated as a putative candidate for effective treatment of some individuals with PTSD.
objectiveTo conduct an interim evaluation of the effectiveness of an eight-session clinical trial of videoconference-based DBR versus waitlist (WL) control for individuals with PTSD.
methodFifty-four individuals with PTSD were randomly assigned to DBR (
resultsSignificant between-group differences in CAPS-total and all subscale scores (re-experiencing, avoidance, negative alterations in cognitions/mood, alterations in arousal/reactivity) were found at post-treatment (CAPS-total: Cohen's
conclusionsThese findings provide emerging evidence for the effectiveness of DBR as a well-tolerated treatment that is based on theoretical advances highlighting alterations to subcortical mechanisms in PTSD and associated symptomatology. Additional research utilizing larger sample sizes, neuroimaging data, and comparisons or adjacencies with other psychotherapeutic approaches is warranted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.