ArticleAnnals of surgery2023
Impact of Portable Normothermic Machine Perfusion for Liver Transplantation From Adult Deceased Donors.
Article in Annals of surgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.
- Machine Perfusion Ameliorates Nonanastomotic Strictures After Liver Transplantation: A Systematic Review and Meta-analysis of Randomized Controlled Trials.Clinical and translational gastroenterology · 2026Pooled it
- Revisiting Futility: Normothermic Perfusion Improves Outcomes Across all UK DCD Risk Strata.Clinical transplantation · 2026Article
- Normothermic Machine Perfusion vs. Static Cold Storage for DBD Liver Transplantation in High-MELD Recipients: A Single-Center Retrospective Study.Journal of hepato-biliary-pancreatic sciences · 2026Article
- Liver transplantation: embracing the future with machine perfusion.Arquivos brasileiros de cirurgia digestiva : ABCD = Brazilian archives of digestive surgery · 2026Review
- Impact of donor-recipient sex-matching patterns on liver transplantation outcomes: a cohort study based on United Network of Organ Sharing data.Hepatobiliary surgery and nutrition · 2025Article
- Dynamic Lactate Clearance Patterns During Normothermic Machine Perfusion Predict Posttransplant Biliary Complications in Donation After Circulatory Death Liver Transplantation.Transplantation direct · 2025Article
- Ischemia-free liver transplantation improves long-term outcomes in a 5-year follow-up study.JHEP reports : innovation in hepatology · 2025Article
- Survey of Early Practices and Perceptions of Liver Machine Perfusion Among US Liver Transplant Surgeons.Transplantation direct · 2025Article
- Liver transplant practices in the era of normothermic machine perfusion in the United States.World journal of transplantation · 2025Article
- Establishing a Normothermic Machine Perfusion Program for Liver Transplantation: Lessons Learned and Early Outcomes in the United States.Clinical transplantation · 2025Article
- Transplantation of Patients with Hepatocellular Carcinoma Through Increased Utilization of Machine Perfusion Technology.Transplantation direct · 2025Article
- Standardization is needed in reporting risk and outcomes of machine perfusion in liver transplantation.Hepatobiliary surgery and nutrition · 2024Article
- Commentary: DCD liver transplant in patients with a MELD over 35.Frontiers in immunology · 2024Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo assess how liver allografts preserved using portable normothermic machine perfusion (NMP) compare against those that underwent ischemic cold storage (ICS) in the setting of donation after brain death (DBD) and donation after circulatory death (DCD) liver transplantation (LT).
backgroundCompared with conventional ICS, NMP may offer more homeostatic preservation, permit physiological assessment of organ function, and provide opportunities for graft improvement/modification. We report a single-center US experience of liver NMP.
methodsA single-center, retrospective analysis of collected data on 541 adult whole LTs from 469 DBD donors [NMP (n = 58) vs ICS (n = 411)] and 72 DCD donors [NMP (n = 52) vs ICS (n = 20)] between January 2016 and December 2022.
resultsIn DBD LT, male sex [odds ratio (95% CI): 1.83 (1.08-3.09)] and >10% macrosteatosis of the donor liver [1.85 (1.10-3.10)] were statistically significant independent risk factors of early allograft dysfunction (EAD). Donor age >40 years and cold ischemia time >7 hours were independent risk factors of reperfusion syndrome (RPS). One-year, 3-year, and 5-year incidences of ischemic cholangiopathy (IC) did not differ significantly in DBD cases between the NMP and ICS cohorts. In DCD LT, NMP was an independent protective factor against EAD [0.11 (0.03-0.46)] and RPS [0.04 (0.01-0.25)]. The incidence of IC in the DCD cases at 1-year and 3-year time points was significantly lower in the NMP cohort (1.9% compared with 20% in the ICS group).
conclusionsCompared with conventional ICS, NMP can significantly reduce the incidence of EAD, RPS, and IC after DCD LT.
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