Evidence map›Paper›PMID 37580849›Full record

ReviewThe Journal of pathology2023

Computational pathology in cancer diagnosis, prognosis, and prediction - present day and prospects.

Gregory Verghese, Jochen K Lennerz, Danny Ruta, Wen Ng, Selvam Thavaraj, Kalliopi P Siziopikou, Threnesan Naidoo, Swapnil Rane, Roberto Salgado, Sarah E Pinder and 1 more

Abstract readReview
In one paragraph

Review in The Journal of pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  6. [Colorectal cancer diagnosis method based on dynamic gland-aware and tissue soft-clustering].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Gregory VergheseSchool of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0009-0006-7638-6431
Jochen K LennerzCenter for Integrated Diagnostics, Department of Pathology, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA.ORCID 0000-0003-2434-4978
Danny RutaGuy's Cancer, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Wen NgDepartment of Cellular Pathology, Guy's and St Thomas NHS Foundation Trust, London, UK.
Selvam ThavarajHead & Neck Pathology, Guy's and St Thomas NHS Foundation Trust, London, UK.ORCID 0000-0001-5720-7422
Kalliopi P SiziopikouDepartment of Pathology, Section of Breast Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-8689-5508
Threnesan NaidooDepartment of Laboratory Medicine and Pathology, Walter Sisulu University, Mthatha, Eastern Cape, South Africa and Africa Health Research Institute, Durban, South Africa.ORCID 0000-0002-1864-4301
Swapnil RaneDepartment of Pathology, Tata Memorial Centre - ACTREC, HBNI, Navi Mumbai, India.ORCID 0000-0002-5374-3903
Roberto SalgadoDepartment of Pathology, GZA-ZNA Ziekenhuizen, Antwerp, Belgium.ORCID 0000-0002-1110-3801
Sarah E PinderSchool of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.
Anita GrigoriadisSchool of Cancer & Pharmaceutical Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID 0000-0003-3434-201X

Funding

Illuminating the evolutionary history of colorectal cancer metastasis: basic principles and clinical applicationsR37CA225655 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI NAXEROVA, KAMILA · 2018 to 2024
$3.0M
Cancer Research UK CTRQQR-2021/100004Medical Research Council MR/X012476/1NCI NIH HHS R37 CA225655Wellcome Trust
6 · The paper itself

Abstract

Computational pathology refers to applying deep learning techniques and algorithms to analyse and interpret histopathology images. Advances in artificial intelligence (AI) have led to an explosion in innovation in computational pathology, ranging from the prospect of automation of routine diagnostic tasks to the discovery of new prognostic and predictive biomarkers from tissue morphology. Despite the promising potential of computational pathology, its integration in clinical settings has been limited by a range of obstacles including operational, technical, regulatory, ethical, financial, and cultural challenges. Here, we focus on the pathologists' perspective of computational pathology: we map its current translational research landscape, evaluate its clinical utility, and address the more common challenges slowing clinical adoption and implementation. We conclude by describing contemporary approaches to drive forward these techniques. © 2023 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

Indexed as

Artificial IntelligenceNeoplasmsAlgorithmsHumansPathologistsPrognosisbiomarkerscomputational pathologydeep learningdigital pathologyhistopathology

Identifiers

PMID37580849
PMCPMC10785705

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.